Nrf2对口腔鳞癌患者TPF诱导化疗效果的影响  

Effect of Nrf2 on TPF induced chemotherapy for oral squamous cell carcinoma

作　　者：赵小妹[1] 夏荣辉[1] 钟来平[1] 朱东旺[1] 张志愿[1] ZHAO Xiao-mei;XIA Rong-hui;ZHONG Lai-ping;ZHU Dong-wang;ZHANG Zhi-yuan(Department of Oromaxillofacial Head and Neck Oncology,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,College of Stomatology,Shanghai Jiao Tong University,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology.Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科,上海交通大学口腔医学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海200011

出　　处：《中国口腔颌面外科杂志》2022年第4期366-370,共5页China Journal of Oral and Maxillofacial Surgery

基　　金：国家自然科学基金(81602370);上海交通大学医学院附属第九人民医院医院管理项目(YGB202111)。

摘　　要：目的:检测核转录相关因子2(Nrf2)在口腔鳞癌组织中的表达,探讨其对TPF诱导化疗效果的影响。方法:选择65例接受TPF诱导化疗的口腔鳞癌患者,采用免疫组织化学方法检测患者活检肿瘤标本中Nrf2的表达,分析Nrf2表达与患者基线资料及预后的关系。采用SPSS 23.0软件包对数据进行统计学分析。结果:生存分析发现,口腔鳞癌患者Nrf2表达与TPF诱导化疗预后显著相关,Nrf2低表达者较高表达者具有更好的总生存率、无疾病生存率、局部无复发生存率、无远处转移生存率。单因素及多因素Cox风险模型分析发现,Nrf2是口腔鳞癌患者TPF化疗的独立预后风险因素。结论:Nrf2表达与口鳞癌患者TPF诱导化疗疗效相关,Nrf2低表达患者预后更好,Nrf2可作为预测口腔鳞癌患者TPF诱导化疗效果的生物标志物。PURPOSE:To examine the expression of nuclear factor erythroid-2 related factor(Nrf2)in oral squamous cell carcinoma(OSCC)and investigate the effect of Nrf2 on TPF induced chemotherapy.METHODS:A total of 65 patients with OSCC who received TPF chemotherapy were selected.Nrf2 expression in the biopsy specimens before treatment was examined by immunohistochemistry.The correlations between Nrf2 expression and clinical factors and clinical response to TPF induced chemotherapy were analyzed.SPSS 23.0 software package was used for data analysis.RESULTS:Survival analysis showed that Nrf2 expression was significantly correlated with the prognosis of TPF induced chemotherapy in OS-CC patients.Patients with higher Nrf2 expression had better overall survival,disease-free survival,local relapse-free sur-vival and distant metastasis free survival.Univariate and multivariate Cox analysis showed that Nrf2 was an independent prognostic risk factor for TPF chemotherapy in OSCC patients.CONCLUSIONS:The expression of Nrf2 is correlated with the efficacy of TPF induced chemotherapy in OSCC patients.Patients with low Nrf2 have a better prognosis,and Nrf2can be used as a biomarker to predict the efficacy of TPF induced chemotherapy in OSCC patients。

关 键 词：NRF2 口腔鳞癌 TPF诱导化疗 预后 

分 类 号：R739.8[医药卫生—肿瘤]