血清肿瘤标志物诊断肺癌的临床价值  

Clinical Value of Serum Tumor Markers in the Diagnosis of Lung Cancer

作　　者：董杰[1] 谢进进 曾秋耀[3] Dong Jie;Xie Jin-jin;Zeng Qiu-yao(Laboratory,Guangzhou Twelfth People's Hospital,Guangzhou 510620,Guangdong Province,China;Laboratory,Clifford Hospital,Guangzhou University of Traditional Chinese Medicine,Guangzhou 511400,Guangdong Province,China;Laboratory,Sun Yat-sen University Cancer Hospital,Guangzhou 510000,Guangdong Province,China)

机构地区：[1]广州市第十二人民医院检验科,广东广州510620 [2]广州中医药大学祈福医院检验科,广东广州511400 [3]中山大学附属肿瘤医院检验科,广东广州510000

出　　处：《中外医药研究》2022年第2期117-119,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:分析胃泌素释放肽前体(ProGRP)、鳞状上皮细胞癌抗原(SCC-Ag)、细胞角蛋白21片段抗原(Cyfra21-1)及癌胚抗原(CEA)诊断肺癌的临床价值。方法:选取2018年10月-2020年10月于广州市第十二人民医院胸外科、呼吸内科确诊为肺癌的50例患者纳入试验组,选取同时期确诊为肺部良性疾病的50例患者纳入观察组,另选取同期在本院进行健康体检的50例健康人纳入参照组。检测所有研究对象治疗前的ProGRP、Cyfra21-1及CEA的水平,对上述指标的诊断灵敏度、特异度、阳性预测值及阴性预测值进行比较,分析其诊断价值。结果:试验组ProGRP、SCC-Ag、Cyfra21-1、CEA水平均高于观察组与参照组,差异有统计学意义(P<0.05);观察组ProGRP、Cyfra21-1、CEA水平均高于参照组,差异有统计学意义(P<0.05)。试验组ProGRP、SCC-Ag、Cyfra21-1、CEA的阳性率及阳性指标均高于观察组与参照组,差异有统计学意义(P<0.05)。ProGRP、SCC-Ag、Cyfra21-1、CEA单一诊断的灵敏度、特异度、准确度、阳性预测值及阴性预测值均低于联合诊断。结论:ProGRP、SCC-Ag、Cyfra21-1及CEA联合诊断肺癌的敏感性高,诊断价值高。Objective:To analyze the clinical value of precursor gastrin-releasing peptide(ProGRP),squamous cell carcinoma an⁃tigen(SCC-Ag),cytokeratin 21 fragment antigen(Cyfra21-1)and carcinoembryonic antigen(CEA)in the diagnosis of lung cancer.Methods:From October 2018 to October 2020,50 patients diagnosed with lung cancer in the Department of Thoracic Surgery and Department of Respiratory Medicine of Guangzhou Twelfth People's Hospital were selected and included in the experimental group.Fifty patients diagnosed with benign lung diseases during the same period were selected and included in the observation group.Another 50 healthy people who underwent physical examination in our hospital during the same period were selected and in⁃cluded in the reference group.The levels of ProGRP,Cyfra21-1 and CEA in all subjects before treatment were detected.The diag⁃nostic sensitivity,specificity,positive predictive value and negative predictive value of the above indicators were compared.Its di⁃agnostic value was analyzed.Results:The levels of ProGRP,SCC-Ag,Cyfra21-1 and CEA in the experimental group were higher than those in the observation group and the reference group,and the difference was statistically significant(P<0.05).The level of ProGRP Cyfra21-1、CEA in the observation group was higher than that in the reference group,and the difference was statisti⁃cally significant(P<0.05).The positive rate and positive indexes of ProGRP,SCC-Ag,Cyfra21-1 and CEA in the experimental group were higher than those in the observation group and the reference group,and the difference was statistically significant(P<0.05).The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of the single diagnosis of ProGRP,SCC-Ag,Cyfra21-1 and CEA were lower than those of the combined diagnosis.Conclusion:ProGRP,SCC-Ag,Cyfra21-1 and CEA combined have high sensitivity and high diagnostic value in the diagnosis of lung cancer.

关 键 词：肺癌 胃泌素释放肽前体 鳞状上皮细胞癌抗原 细胞角蛋白21片段抗原 癌胚抗原 

分 类 号：R73[医药卫生—肿瘤]