2-烯基苯并噻唑衍生物的合成与表征综合实验  

Synthesis and Characterization of 2-alkenylbenzo[d]thiazole Derivatives

作　　者：李清寒[1] 周林 杨晓练 Li Qinghan;Zhou Lin;Yang Xiaolian(College of Chemistry and Environment,Southwest Minzu University,Chengdu Sichuan 610041;No.1 Middle School of Chongqing Xiushan Tujia Nationality and Miao Nationality Autonomous County,Chongqin 274399)

机构地区：[1]西南民族大学化学与环境学院,四川成都610041 [2]重庆市秀山土家族苗族自治县第一中学校,重庆274399

出　　处：《山西化工》2022年第4期6-9,共4页Shanxi Chemical Industry

基　　金：西南民族大学一流本科课程建设项目——“绿色化学”(No.2020YLKC24)。

摘　　要：设计了2-烯基苯并[d]噻唑衍生物的合成与表征综合实验。实验主要包括:通过亲核取代反应、炔烃的氢化反应、Niegish偶联反应合成2-(1-戊烯基)-6-氟苯并[d]噻唑化合物;并运用核磁共振(NMR)技术(1HNMR,13CNMR),紫外光谱和质谱研究其结构。通过该综合实验,学生可以比较完整、系统地了解有机合成的主要步骤与有机化合物的表征方法,并且通过分析NMR谱图和质谱,理解核磁共振技术和质谱在有机合成中确定未知物的重要作用。教学实践中表明,该综合试验取得了较好的教学效果。This paper aims to design a comprehensive chemical experiment of synthesis and characterization of 2-alkenylbenzo[d]thiazole derivatives.The experiment mainly includes:synthesis of new 2-alkenylbenzo[d]thiazole derivatives by nucleophilic substitution,hydrogenation of alkynes and Niegish cross-coupling reaction,and the analysis of chemical structure by NMR(1H NMR,13CNMR),UV and MS techniques.Consequently,the students can master the main steps and characterization methods of organic synthesis,and realize the important role of nuclear magnetic resonance technique in determining the structure of new compound.It is proven that the comprehensive experiment has achieved favorite results in practice teaching.

关 键 词：综合实验 2-烯基苯并[d]噻唑衍生物 实验教学 合成 

分 类 号：O621.3[理学—有机化学]