A third dose of inactivated SARS-CoV-2 vaccine induces robust antibody responses in people with inadequate response to two-dose vaccination  被引量:1

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作  者:Taicheng Zhou Tianpei Shi Ao Li Lingzhi Zhu Xinshuai Zhao Naiyin Mao Wanting Qin Hanfang Bi Mei Yang Muxian Dai Fengwei Liu Rong Wang Wei Su Liang Zhang Wenbo Xu Jia Wei Zijie Zhang 

机构地区:[1]Central Laboratory and Liver Disease Research Center,The Affiliated Hospital of Yunnan University,Yunnan University,China [2]State Key Laboratory for Conservation and Utilization of Bio-resource and School of Life Sciences,Yunnan University,China [3]State Key Laboratory of Genetic Resources and Evolution,and Yunnan Laboratory of Molecular Biology of Domestic Animals,Kunming Institute of Zoology,Chinese Academy of Sciences,China [4]College of Life Science,University of Chinese Academy of Sciences,China [5]NHC Key Laboratory of Medical Virology and Viral Diseases,National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,China

出  处:《National Science Review》2022年第7期7-9,共3页国家科学评论(英文版)

摘  要:Mass application of SARS-CoV-2 vaccines is a major approach to reduce SARS-CoV-2 transmission and COVID19 symptoms worldwide.The inactivated SARS-CoV-2 vaccine is one of the most widely administered vaccine types in many countries,with over 2 billion doses administered as of 31 August 2021.However,clinical trials estimate 65%–85%protection from detectable symptoms for inactivated SARS-CoV-2 vaccines[1–4],with 15%–35%of people remaining insufficiently protected after two-dose immunization.Immune protectionforthese‘non-responders’is critical for population immunity as established by mass vaccination.A third dose of inactivated(CoronaVac)vaccine has been shown to boost antibody response by between 3–5 folds in the general population[5].Whether a third dose can induce an adequate antibody response in‘non-responders’remains unclear.Here we report a trial of a third dose in a cohort of 105 vaccinated participants(Supplementary Fig.S1)with suboptimal antibody responses(non-responders)aftertwo doses(43.8%were men;average age 43±11 years[±SD];average BMI 23.5±3.4[±SD],Supplementary Table S1).

关 键 词:VACCINE doses VACCINATION 

分 类 号:R186[医药卫生—流行病学]

 

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