Delayed post-hypoxic leukoencephalopathy following barbiturate overdose: A case report  

作　　者：Arshi Syal Samiksha Gupta Monica Gupta Gautam Jesrani Yajur Arya 

机构地区：[1]Department of General Medicine,Government Medical College and Hospital,Chandigarh,India

出　　处：《Journal of Acute Disease》2022年第4期165-167,共3页急性病杂志（英文版）

摘　　要：Rationale:Delayed post-hypoxic leukoencephalopathy(DPHL)is usually an overlooked condition,which arises as a result of a multitude of reversible and irreversible conditions.Patient’s Concern:A 50-year-old female with a history of epilepsy,who developed DPHL 12 days after respiratory failure secondary to barbiturate toxicity.Diagnosis:DPHL on magnetic resonance imaging of the brain.Interventions:Mechanical ventilation was initiated for respiratory failure and hemodialysis for barbiturate toxicity.Outcomes:The patient developed akinetic mutism due to infirmity and had a residual disability,which led to permanent dependency.Lessons:The diagnosis of DPHL is often delayed or missed,given the rarity of this condition and its inconsistent clinical symptomatology.Diagnostic delay can be avoided by early recognition of the classical“delayed onset”symptoms.

关 键 词：Delayed post-hypoxic leukoencephalopathy Barbiturate overdose Epilepsy Respiratory failure Akinetic mutism 

分 类 号：R742[医药卫生—神经病学与精神病学]