术后放疗对老年食管癌患者生活质量、复发和生存情况的影响  

Effect of postoperative radiotherapy on the quality of life,recurrence,and survival in elderly patients with esophageal cancer

作　　者：郝炎萍 袁莹 左予[1] HAO Yanping;YUAN Ying;ZUO Yu(Department of Radiotherapy,Xinxiang Central Hospital,Xinxiang 453000,He’nan,China)

机构地区：[1]新乡市中心医院放疗科,河南新乡453000

出　　处：《癌症进展》2022年第15期1594-1596,1600,共4页Oncology Progress

摘　　要：目的探讨术后放疗对老年食管癌患者生活质量、复发和生存情况的影响。方法根据治疗方式的不同将82例老年食管癌患者分为观察组和对照组,每组41例,对照组患者进行单纯手术治疗,观察组患者在对照组的基础上进行术后放疗。比较两组患者的生活质量[欧洲癌症研究与治疗组织生命质量测定量表(EORTC QLQ-C30)]、血清癌胚抗原(CEA)水平、住院时间、治疗后复发率及生存率。结果治疗后6个月,两组患者的社会功能、角色功能、认知功能、躯体功能、情绪功能评分均高于本组治疗前,且观察组患者的上述评分均高于对照组,差异均有统计学意义(P﹤0.05)。治疗后,两组患者的血清CEA水平均明显低于本组治疗前,且观察组患者的血清CEA水平明显低于对照组,差异均有统计学意义(P﹤0.01)。两组患者的住院时间比较,差异无统计学意义(P﹥0.05)。观察组患者的1、2年复发率均低于对照组,差异均有统计学意义(P﹤0.05)。两组患者的1、2年生存率比较,差异均无统计学意义(P﹥0.05);观察组患者的3年生存率高于对照组,差异有统计学意义(P﹤0.05)。结论老年食管癌患者术后采用放疗可有效降低血清CEA水平,改善生活质量,降低疾病复发率,提高生存率,临床应用价值较高。Objective To investigate the effect of postoperative radiotherapy on the quality of life,recurrence,and survival of elderly patients with esophageal cancer.Method A total of 82 elderly patients with esophageal cancer were divided into observation group and control group according to different treatment methods,with 41 cases in each group.The patients in the control group were treated with surgery alone,and the patients in the observation group were treated with postoperative radiotherapy based on the control group’s regimen.The quality of life[European Organization for Research and Treatment of Cancer quality of life questionnaire core 30(EORTC QLQ-C30)],serum carcinoembryonic antigen(CEA)level,hospitalization time,post-treatment recurrence rate,and survival rate were compared between the two groups.Result Six months after the treatment,the scores of social function,role function,cognitive function,physical function,and emotional function of the two groups were higher than those before the treatment,and the foregoing scores of the observation group were higher than those of the control group,and the differences were statistically significant(P0.05).The 1-and 2-year recurrence rates in the observation group were lower than those in the control group,and the differences were statistically significant(P0.05),while the 3-year survival rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Postoperative radiotherapy for elderly patients with esophageal cancer could effectively reduce serum CEA level,improve quality of life,reduce disease recurrence rate,and improve survival rate with high clinical application value.

关 键 词：放疗 食管癌 癌胚抗原 生活质量 生存率 复发率 

分 类 号：R735.1[医药卫生—肿瘤]