D型人格慢性萎缩性胃炎早期癌变危险因素分析  

Risk factors for early canceration of chronic atrophic gastritis in patients with type D personality

作　　者：李剑[1] 廖莹峰 LI Jian;LIAO Ying-feng(Department of Geriatrics/Gastroenterology,Nephropathy and Endocrinology,Shenmu Hospital Affiliated to Northwest University,Yulin 719300,China;Department of Rheumatology,Immune,Nephropathy and Endocrinology,Shenmu Hospital Affiliated to Northwest University,Yulin 719300,China)

机构地区：[1]陕西省西北大学附属神木医院老年病(消化)科,榆林719300 [2]陕西省西北大学附属神木医院风湿免疫肾病内分泌科,榆林719300

出　　处：《中国肿瘤临床与康复》2022年第7期806-810,共5页Chinese Journal of Clinical Oncology and Rehabilitation

基　　金：榆林市科学技术研究与发展计划自筹项目((2020)46号)。

摘　　要：目的 探讨D型人格慢性萎缩性胃炎早期癌变的危险因素。方法 选取2018年1月至2021年1月间西北大学附属神木医院收治的40例D型人格慢性萎缩性胃炎早期癌变患者作为研究对象,将其纳入早期癌变组,选取同期收治的40例D型人格慢性萎缩性胃炎患者纳入非早期癌变组,另选取40例慢性萎缩性胃炎患者纳入对照组。对比三组患者的临床特征、心理状态、饮食习惯和相关病史等,对比三组患者血清肿瘤标志物含量。采用Logistic回归分析D型人格慢性萎缩性胃炎早期癌变危险因素。结果 三组患者性别、胃癌家族史、急躁、长期喝咖啡和吃隔夜菜情况比较,差异无统计学意义(P>0.05)。三组患者年龄、抑郁、焦虑、长期吸烟饮酒、长期饮浓茶、饮食不规律、进食偏快、常吃腌制食物以及幽门螺旋杆菌(Hp)感染史等情况比较,差异均有统计学意义(均P<0.05)。三组患者糖链抗原(CA)19-9、CA72-4与癌胚抗原(CEA)水平有差异,且早期癌变组高于非早期癌变组与对照组,差异均有统计学意义(均P<0.05),但非早期癌变组与对照组的CA19-9、CEA表达水平比较,差异无统计学意义(P>0.05)。Logistic回归分析结果表明,抑郁、长期吸烟、长期饮酒、长期饮浓茶、常吃腌制食物、Hp感染史和CA72-4水平降低为D型人格慢性萎缩性胃炎早期癌变的独立危险因素,差异均有统计学意义(均P<0.05)。结论 D型人格慢性萎缩性胃炎早期癌变患者普遍会存在年龄大、抑郁、焦躁、长期饮酒、长期饮浓茶、饮食不规律、进食偏快、常吃腌制食物、Hp感染史以及CA19-9、CA72-4与CEA水平升高情况,其中,抑郁、长期吸烟、长期饮酒、长期饮浓茶、常吃腌制食物、Hp感染史和CA72-4水平降低为D型人格慢性萎缩性胃炎早期癌变的独立危险因素。Objective To explore the risk factors of early canceration of chronic atrophic gastritis in patients with type D personality. Methods From January 2018 to January 2021, 40 patients of type D personality with early canceration of chronic atrophic gastritis were selected at Shenmu Hospital Affiliated to Northwest. They were included in an early canceration group. Another 40 patients of type D personality with chronic atrophic gastritis were selected in the same period and were included in a nonearly canceration group. Moreover, extra 40 patients with chronic atrophic gastritis were selected and included in a control group. Clinical characteristics, psychological status, dietary habit, relevant disease histories and levels of serum tumor markers were compared among the three groups. Logistic regression was used to analyze the risk factors for early canceration of chronic atrophic gastritis in patients with type D personality. Results There were no significant differences among the three groups in gender, family history of gastric cancer, anxiety, long-term drinking coffee and eating overnight dishes(P>0.05). There were significant differences in age, depression, anxiety, long-term smoking, drinking alcohol and drinking strong tea, irregular diet, fast eating, frequent eating pickled food and H.pylori infection among the three groups(all P<0.05). The levels of carbohydrate antigen 19-9(CA19-9), CA72-4 and carcinoembryonic antigen(CEA) were significantly different among the three groups. The levels of CA19-9, CA72-4 and CEA were significantly higher in the early canceration group than in the nonearly canceration group and the control group(all P<0.05). However, there was no significant difference between the nonearly canceration group and the control group(P<0.05). Logistic regression analysis showed that depression, long-term smoking, long-term drinking alcohol, long-term drinking of strong tea, frequent eating of pickled food, history of H.pylori infection and decreased CA72-4 level were independent risk factors for

关 键 词：D型人格 慢性萎缩性胃炎 早期癌变 肿瘤标志物 危险因素 

分 类 号：R735.2[医药卫生—肿瘤]