常春藤素抗肿瘤作用及机制研究进展  

Anti-tumor Effect and Mechanisms of Hederin: A Review

作　　者：张小雨 王雪振 夏雷[1] ZHANG Xiaoyu;WANG Xuezhen;XIA Lei(Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学,济南250355

出　　处：《中国实验方剂学杂志》2022年第15期275-282,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81703839)。

摘　　要：常春藤素是一种从紫草、白头翁、铁线莲等多种草本植物中提取的单枝三萜皂苷类天然活性成分,其因抗炎、抗痉挛、抗氧化、抗利什曼原虫病等多重药理功效备受关注。研究发现,常春藤素具有显著的抗肿瘤生物活性,有望成为潜在治疗恶性肿瘤的药物。迄今为止,多项研究表明,常春藤素可通过促进肿瘤细胞凋亡,抑制肿瘤细胞增殖、转移及侵袭,诱导肿瘤细胞自噬等作用在乳腺癌、肺癌、肝癌和胰腺癌等多种恶性肿瘤中均表现出其有抗肿瘤功效,其抗肿瘤活性的作用机制主要体现在可通过调节胞内磷脂磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)通路、线粒体中活性氧(ROS)、微小RNA(miRNA)触发肿瘤凋亡;其抗增殖活性主要体现在对细胞周期蛋白(cyclin)和细胞周期蛋白依赖性激酶(CDK)的调节作用;其通过阻断上皮间转化(EMT)进程等抑制肿瘤细胞的转移和侵袭。此外常春藤素还可以通过影响肿瘤代谢重编程,诱导肿瘤细胞自噬等发挥其抗肿瘤作用。常春藤素抗肿瘤作用机制广泛,将来可能成为新型抗肿瘤药物,为常春藤素在抗肿瘤领域的研究开拓思路。目前,针对常春藤素的研究较少且缺乏对常春藤素抗肿瘤作用机制的系统性综述,为此,该研究基于常春藤素抗肿瘤作用进行文献综述,以期为科研和临床工作者提供借鉴及参考信息。Hederin is a natural active component of triterpenoid saponins extracted from many medicinal herbs, such as Lithospermum erythrorhizon, Pulsatilla chinensis, and Clematis florida. It has attracted much attention from doctors for its anti-inflammatory, anti-convulsive, anti-oxidation and anti-leishmaniasis activities. Hederin has significant anti-tumor bioactivity and is expected to be a potential drug for the treatment of malignant tumors. The available studies have demonstrated that hederin can promote the apoptosis, inhibit the proliferation, metastasis, and invasion, and induce the autophagy of tumor cells, exhibiting a promising prospect in the treatment of breast cancer, lung cancer, liver cancer, and pancreatic cancer. Specifically, hederin can regulate the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) pathway, reactive oxygen species (ROS), and microRNA (miRNA) to trigger tumor cell apoptosis. Its anti-proliferation activity is mainly reflected in the regulation of cyclin and cyclin-dependent kinase (CDK). Hederin inhibits the metastasis and invasion of tumor cells by blocking epithelial-mesenchymal transformation (EMT). In addition, hederin can influence metabolic reprogramming to induce tumor cell autophagy. Hederin is involved in a variety of pathways to exert its anti-tumor activity and may become a novel anti-tumor drug in the future, which give new sights into the study of hederin in the anti-tumor field. There are few studies about hederin and no systematic review of its anti-tumor mechanisms. Therefore, this study reviewed the studies about the anti-tumor mechanism of hederin, aiming to provide reference and information for researchers and clinical staff.

关 键 词：常春藤素 肿瘤 分子机制 研究进展 

分 类 号：R22[医药卫生—中医基础理论] R242[医药卫生—中医学] R2-031R2-0R285.5