A randomized study of network-based perception learning in the treatment of amblyopia children  

作　　者：Chang-Yue Zheng Wei Xu Shun-Qiang Wu Dong-Xu Han 

机构地区：[1]Department of Ophthalmology,Eye and ENT Hospital Affiliated to Fudan University,Shanghai,China [2]NHC Key Laboratory of Myopia Fudan University [3]Key Laboratory of Myopia,Chinese Academy of Medical Sciences Fudan University,Shanghai,China

出　　处：《International Journal of Ophthalmology(English edition)》2022年第5期800-806,共7页国际眼科杂志（英文版）

基　　金：Shanghai Health Situation Project (No.201540252);Shanghai Tongji Hospital Clinical Research Incubation Project [No.ITJ(QN)1812];Shanghai Science and Technology Committee (STCSM) Science and Technology Innovation Program (No.20S31906000)。

摘　　要：AIM:To compare the effectiveness of network-based perception learning(NBPL) and traditional training in the treatment of amblyopia children.METHODS:This randomized controlled clinical trial recruited 56 participants aged 4-12 y with anisometropic and/or strabismic amblyopia. Participants were randomly divided into two groups:the NBPL group(n=28) who received patching and NBPL for 3 mo, and the control group(n=28) who got 3 mo of patching and traditional training. Best-corrected visual acuity(BCVA) in the amblyopic eye and stereoacuity were measured and compared at baseline, 1, 2, and 3 mo post-randomization.RESULTS:There were no significant differences in age, gender ratio, and BCVA between the two groups at baseline. At 3 mo, most patients gained lines(2 log MAR lines on average) of BCVA in both groups except one 11-year-old girl in the control group(P<0.05). But no significant difference in BCVA improvement of the amblyopic eye between the two groups was found(P=0.725), and amblyopia resolved(BCVA of 0.1 log MAR or better or within 1 log MAR line of the fellow eye) for 13(46.4%) participants in both groups. The number of patients with improvement of stereoacuity was 25 and 13 in the NBPL group and control group(P=0.041), respectively, and a significant difference exists in the distribution of stereopsis at 3 mo between the two groups(P=0.015). Besides, in patients with measurable stereopsis improvement degree and space for improvement in the two groups, the NBPL group also achieved better stereoscopic improvement than the control group(10/11 vs 4/11, P<0.05).CONCLUSION:The NBPL system has a significant effect on the improvement of BCVA and stereoacuity of amblyopia children and is better than traditional training in terms of stereoacuity improvement. Perceptual learning visual training may play a more important role in the treatment of amblyopia in the future.

关 键 词：AMBLYOPIA perceptual learning STEREOACUITY best-corrected visual acuity 

分 类 号：R777.44[医药卫生—眼科]