Effects of anti-TNF biologic drugs on uveitis severity in Behcet patients: systematic review and Meta-analysis  

作　　者：Somayeh Abolhasani Alireza Khabbazi Foroogh Hosseini Shiva Gholizadeh-Ghaleh Aziz Shahriar Alipour 

机构地区：[1]Department of Biochemistry,Faculty of Medicine,Urmia University of Medical Sciences,Urmia 5111,Iran [2]Student Research Committee,Urmia University of Medical Sciences,Urmia 5111,Iran [3]Connective Tissue Diseases Research Center,Tabriz University of Medical Science,Tabriz 4766,Iran [4]Department of Biochemistry,Faculty of Medicine,Tabriz University of Medical Sciences,Tabriz 4766,Iran

出　　处：《International Journal of Ophthalmology(English edition)》2022年第5期813-819,共7页国际眼科杂志（英文版）

摘　　要：AIM:To investigate effects of anti-TNF biologic drugs on uveitis severity(comparing visual acuity log MAR levels) in Behcet patients.METHODS:Three databases Pub Med, Scopus, and the Web of Science were searched for qualified papers focusing on the anti-TNF-α factors treatment in Behcet’s disease(BD)-associated uveitis. Studies that were designed pre and post anti-TNF drug treatment, were selected. After determining the search strategy for this study, the relevant data were extracted. RESULTS:The initial search was performed in the target databases and a total of about 1458 articles were found. Fifteen articles were selected for systematic review and only 12 of them had inclusion criteria for Meta-analysis(with visual acuity data). The mean dose of prednisolone before and after biological treatments was reported in 5 studies(28.56 and 7.56 mg/kg, respectively). Also, the preliminary results indicate a significant reduction in visual acuity log MAR levels(MD=-1.5 IU/L, 95%CI:-2.1,-0.01).CONCLUSION:Biological drugs significantly reduce the dose of prednisolone and affect visual acuity values.

关 键 词：anti-TNF drugs Behcet’s disease INFLIXIMAB UVEITIS visual acuity 

分 类 号：R773.9[医药卫生—眼科] R597.9[医药卫生—临床医学]