糖类抗原19-9联合骨桥蛋白诊断胰腺癌及预后的相关性分析  

Correlation analysis of carbohydrate antigen 19-9 combined with osteopontin in the diagnosis and prognosis of pancreatic cancer

作　　者：于艳华 谢文瑞 Yu Yanhua;Xie Wenrui(Department of Laboratory Medicine,Xianyang Hospital,Yan'an University,Shaanxi 712000,China)

机构地区：[1]延安大学咸阳医院检验科,712000

出　　处：《山西医药杂志》2022年第13期1447-1451,共5页Shanxi Medical Journal

摘　　要：目的探讨糖类抗原199(CA19-9)联合骨桥蛋白(OPN)诊断胰腺癌及预后的相关性。方法将75例我院收治的疑似胰腺癌患者纳入本次研究,病例选择范围为2019年1月至2021年6月。以病理组织学结果作为金标准,分别检测2组患者CA19-9水平和OPN水平并分析其对于胰腺癌的诊断价值,采用Logsitic回归分析研究OPN、CA19-9与胰腺癌预后的关系。结果经病理组织学检测75例疑似胰腺癌患者中,52例确诊为胰腺癌,占比69.3%,23例为良性胰腺病变,占比30.7%。胰腺癌组CA19-9和OPN水平均明显高于良性胰腺病变组(P<0.05)。CA19-9单独诊断胰腺癌的灵敏度、特异度、阳性预测值、阴性预测值分别为88.5%、78.3%、90.2%、75.0%,OPN单独诊断胰腺癌的灵敏度、特异度、阳性预测值、阴性预测值分别为94.2%、91.3%、96.1%、87.5%,CA19-9联合OPN诊断胰腺癌的灵敏度、特异度、阳性预测值、阴性预测值分别为86.5%、65.2%、84.9%、68.2%。存活组CA19-9和OPN水平均明显低于死亡组(P<0.05),CA19-9水平和OPN水平均为影响胰腺癌病死的危险因素(P<0.05),差异有统计学意义。结论糖类抗原199联合骨桥蛋白对于胰腺癌具有一定的诊断价值,对于患者预后情况有一定的预测价值。Objective To explore the correlation of carbohydrate antigen 19-9(CA19-9)combined with osteopontin(OPN)in the diagnosis and prognosis of pancreatic cancer.Methods Seventy and five cases of suspected pancreatic cancer patients admitted to our hospital from January 2019 to June 2020 were included in this study.Using histopathological results as the gold standard,the levels of CA19-9 and OPN were detected in the two groups of patients and their diagnostic value for pancreatic cancer was analyzed.Logisticc regression analysis was used to study the relationship between OPN,CA19-9 and the prognosis of pancreatic cancer.Results Of the 75 suspected pancreatic cancer patients tested by histopathology,52 were diagnosed with pancreatic cancer,accounting for 69.3%,and 23were benign pancreatic lesions,accounting for 30.7%.The levels of CA19-9 and OPN in the pancreatic cancer group were significantly higher than those in the benign pancreatic disease group(P<0.05).The sensitivity,specificity,positive predictive value,and negative predictive value of CA19-9 alone in the diagnosis of pancreatic cancer were 88.5%,78.3%,90.2%,and 75.0%,respectively.The sensitivity,specificity,positive predictive value,and negative predictive values of OPN alone in the diagnosis of pancreatic cancer were 94.2%,91.3%,96.1%,and 87.5%.The sensitivity,specificity,positive predictive value,and negative predictive value of CA19-9 combined with OPN in the diagnosis of pancreatic cancer were 86.5%,65.2%,84.9%,and 68.2%,respectively.The levels of CA19-9 and OPN in the survival group were significantly lower than those in the death group(P<0.05).Both CA19-9 and OPN levels were risk factors affecting pancreatic cancer death,and the difference was statistically significant(P<0.05).Conclusion CA19-9 combined with OPN has a certain diagnostic value for pancreatic cancer and predictive value for the prognosis of patients.

关 键 词：胰腺肿瘤 糖类抗原199 骨桥蛋白质 诊断 预后 

分 类 号：R735.9[医药卫生—肿瘤]