黑水虻抗菌肽研究进展  

Research Progress of Antimicrobial Peptides from Black Soldier Fly

作　　者：章启慧 李昆太[1,2] 王会 王飞 王雷雨[3] 陈玉梁 杨钰妮 ZHANG Qihui;LI Kuntai;WANG Hui;WANG Fei;WANG Lei-yu;CHEN Yuliang;YANG Yu-ni(College of Biological Sciences and Engineering,Jiangxi Agricultural University,Nanchang 330045,China;College of Food Science and Technology,Guangdong Ocean University,Zhanjiang,Guangdong 524088,China;Agricultural Products Processing Research Institute,Chinese Academy of Tropical Agricultural Sciences,Zhanjiang,Guangdong 524001,China;College of Agricultural and Food Engineering,Baise University,Baise,Guangxi 533000,China)

机构地区：[1]江西农业大学生物科学与工程学院,江西南昌330045 [2]广东海洋大学食品科技学院,广东湛江524088 [3]中国热带农业科学院农产品加工研究所,广东湛江524001 [4]百色学院农业与食品工程学院,广西百色533000

出　　处：《江西农业大学学报》2022年第4期996-1004,共9页Acta Agriculturae Universitatis Jiangxiensis

基　　金：海南省自然科学基金青年基金项目(SQ2021QNJJ0380);广东省普通高校重点领域专项(2021ZDZX4010)。

摘　　要：目前细菌对抗生素的耐药性已经成为全球性问题,滥用抗生素使细菌的耐药性急剧增加,尤其是当前严令禁止在动物饲料中添加抗生素,迫使人们寻找抗生素的替代品。昆虫因其自身免疫系统而产生的抗菌肽因具有良好的抑菌活性、稳定性及安全性,被认为是最有可能替代抗生素的产品之一。黑水虻腐生性水虻科昆虫,具有生长繁殖迅速且有极佳的农业或餐厨有机废弃物吸收转化的能力,加之所产生的抗菌肽具有稳定且广谱的抗菌性能,成为昆虫抗菌肽领域中最具有代表性的昆虫之一。通过回顾近年研究成果,从黑水虻抗菌肽的制备与纯化方法、黑水虻抗菌肽的产生机制、黑水虻抗菌肽的抑菌机制与评价方法、黑水虻抗菌肽的应用等方面进行了系统阐述,以期为黑水虻抗菌肽的开发与利用提供一定参考。Bacterial resistance to antibiotics has become a global problem.The misuse of antibiotics has led to a rapid increase in bacterial resistance,especially with the current strict ban on the addition of antibiotics into animal feed,forcing the search for alternatives to antibiotics.Due to their good antibacterial activity,stability and safety,antimicrobial peptides produced by the immune system of insects are considered to be one of the most likely alternatives to antibiotics..Among them,black soldier fly(Diptera:Stratiomyidae),growing up and reproducing rapidly,has excellent ability to absorb and transform agricultural or kitchen organic garbage,and the produced antimicrobial peptide has stable and broad-spectrum antimicrobial properties.Therefore,black soldier fly is regarded as one of the most representative insects in the field of insect antimicrobial peptides.By reviewing the literature in recent years,this paper systematically introduces the preparation and purification methods of antimicrobial peptides from black soldier fly,the production mechanisms,the inhibition mechanisms and evaluation methods,and the application,thus providing reference for the development and utilization of antimicrobial peptides from black soldier fly.

关 键 词：昆虫 黑水虻 抗菌肽 抑菌 

分 类 号：S899.9[农业科学—特种经济动物饲养] Q969.447.5[农业科学—畜牧兽医]