The action mechanism of Rhizoma Imperatae for pediatric epistaxis management using a network pharmacology approach  

作　　者：Xiao-Hong Fan Dong-Ju Chen Li-Mei Wang 

机构地区：[1]Chongqing Precision Medical Industry Technology Research Institute,Chongqing 400000,China [2]Department of Cardiothoracic Surgery,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China [3]Department of Respiratory and Critical Care Medicine,People’s Hospital of Chongqing Ba’nan District,Chongqing 401320,China

出　　处：《TMR Pharmacology Research》2022年第3期36-41,共6页TMR药理学研究

摘　　要：Background:Pediatric epistaxis is one of the most common and frequently occurring diseases,while its pathogenesis is complicated and remains to be fully elucidated.Objective:This work aims to explore the therapeutic effect and action mechanism of Rhizoma Imperatae in the treatment of pediatric epistaxis in a network pharmacology approach and to provide a practical reference for treating epistaxis in children.Methods:The active ingredients of Chinese herb Rhizoma Imperatae were obtained from the TCMSP database,and the targets of chemical compounds were subsequently predicted using the Swisstargetprediction database;the disease targets of epistaxis were exported from the Genecards database;the obtained overlapped genes were applied for protein-protein interaction(PPI)analysis,Gene Ontology(GO)anlysis and KEGG analysis.Results:There were 128 targets of Rhizoma Imperatae were predicted,and 500 disease targets were collected,with 19 overlapped targets between the drug and the disease.The five genes matrix metallopeptidase 9(MMP9),EGFR,JUN,PTGS1,and ESR1 had the most connections based on the PPI analysis.The GO analysis indicated that positive regulation of vascular smooth muscle cell proliferation and positive regulation of smooth muscle cell proliferation were greatly associated with MMP9,EGFR,and JUN genes in biological processes(BP)and positive regulation of lipid kinase activity and nitric-oxide syntheses activity affected EGFR and ESR1 genes mostly in molecular function(MF).Conclusion:The present research results demonstrated that Rhizoma Imperatae might play a role in alleviating pediatric epistaxis using a network pharmacology technique,hoping to figure out its action mechanism of the drug against the disease.

关 键 词：Rhizoma Imperatae pediatric epistaxis network pharmacology action mechanism 

分 类 号：R73[医药卫生—肿瘤]