齐拉西酮致口吃1例  

Ziprasidone-induced stuttering:a case report

作　　者：孙振晓[1] 刘化学[1] Sun Zhenxiao;Liu Huaxue(Mental Health Center of Linyi,Linyi 276005,China)

机构地区：[1]临沂市精神卫生中心,山东临沂276005

出　　处：《四川精神卫生》2022年第4期373-375,共3页Sichuan Mental Health

摘　　要：本文报告了一例25岁男性精神分裂症患者接受奥氮平联合苯海索治疗,精神症状缓解。因又出现幻听,故加用齐拉西酮治疗,4天后患者出现口吃,停用齐拉西酮2天后口吃消失,再次加用齐拉西酮后口吃又出现,停用后口吃消失。遂将奥氮平增至20 mg/d治疗,精神症状渐稳定。4个月后复诊,患者精神症状稳定,未再出现口吃,提示系齐拉西酮所致口吃。本案例提示:临床上在应用齐拉西酮时,应考虑到其引起口吃的可能性。This paper reported a case of a 25-year-old male schizophrenic patient,who obtained remission from psychotic symptoms during the treatment of olanzapine and trihexylphenidyl,was given ziprasidone treatment additionally due to the occurrence of auditory hallucination,and developed stuttering 4 days later.The stuttering disappeared 2 days following the discontinuation of therapy,and reappeared after reinstitution of ziprasidone therapy,but disappeared again after discontinuation.The dose of olanzapine was increased to 20 mg/d to ensure the stability of psychotic remission.At a follow-up visit 4 months later,the patient’s mental condition was stable and stuttering did not recur,indicating that the stuttering was induced by ziprasidone.This case suggests that the possibility of stuttering as an adverse reaction should be considered in the clinical application of ziprasidone.

关 键 词：齐拉西酮 口吃 不良反应 

分 类 号：R749[医药卫生—神经病学与精神病学]