中枢神经调节剂在老年功能性胃肠病中的应用现状  

Application status of central neuromodulators for functional gastrointestinal disorders in the elderly

作　　者：董晓宇 廖亮 石卉 DONG Xiao-Yu;LIAO Liang;SHI Hui(Department of Gastroenterology,Second Medical Center,Chinese PLA General Hospital,National Clinical Research Center for Geriatric Diseases,Beijing 100853,China)

机构地区：[1]中国人民解放军总医院第二医学中心消化内科,国家老年疾病临床医学研究中心,北京100853

出　　处：《中华老年多器官疾病杂志》2022年第8期621-624,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：解放军总后勤部卫生部科研基金(17BJZ46);中央保健科研课题(W2017BJ17)。

摘　　要：功能性胃肠病是一组根据胃肠道症状分类的疾病,其症状产生主要与脑-肠轴功能异常、动力紊乱、内脏高敏感、黏膜和免疫功能的改变、肠道菌群的改变、中枢神经系统处理功能异常相关,在老年患者中发病率较高。单用常规药物治疗该病多难以缓解症状,辅以中枢神经调节剂则可明显改善症状。然而老年人多存在共病状态,因此在应用中枢神经调节剂时,应注意药物种类、剂量和药物间相互作用,避免毒副作用。本文主要对中枢神经调节剂在老年功能性胃肠病患者中对不同转运蛋白和受体的调节机制和作用、临床应用及副反应进行综述,以期对老年功能性胃肠病患者应用中枢神经调节剂提供参考依据。Functional gastrointestinal disorders are a group of diseases classified by gastrointestinal symptoms,whose symptoms are mainly related to abnormal brain-intestinal axis,motility disorders,visceral hypersensitivity,changes in mucosal and immune function,changes in intestinal flora,and abnormal processing of the central nervous system.The prevalence of functional gastrointestinal disor-ders is quite high in the elderly patients.It is difficult to relieve the symptoms with conventional drugs alone,while neuromodulators of central nervous system can significantly improve the symptoms.However,the elderly often have comorbid conditions.Therefore,when using central nervous system modulators,attention should be paid to the type,dosage and drug-drug interactions to avoid toxic and side effects.In this paper,we mainly review the regulatory mechanism and effect,clinical application and side effects of the neuromodulators of central nervous system on different transporters and receptors in order to provide reference for their application for elderly patients with functional gastrointestinal disorders.

关 键 词：老年人 中枢神经调节剂 功能性胃肠病 副反应 

分 类 号：R574[医药卫生—消化系统]