^(18)F-FDG PET-CT评估乳腺浸润性导管癌临床及病理特征的研究  

Study on the value of ^(18)F-FDG PET-CT in the evaluation of the clinical and pathological features of invasive ductal carcinoma of breast

作　　者：薛杨央[1] 汪会[1] 余文静 张丹[1] 徐慧琴[1] XUE Yang-yang;WANG Hui;YU Wen-jing;ZHANG Dan;XU Hui-qin(Department of Nuclear Medicine,The First Affiliated Hospital of Anhui Medical University,Hefei Anhui 230000,China)

机构地区：[1]安徽医科大学第一附属医院核医学科,安徽合肥230000

出　　处：《蚌埠医学院学报》2022年第8期1078-1082,1087,共6页Journal of Bengbu Medical College

基　　金：国家自然科学基金项目(81971643)。

摘　　要：目的:评估^(18)F-脱氧葡萄糖正电子发射计算机断层扫描(^(18)F-FDG PET-CT)代谢参数与乳腺浸润性导管癌临床病理学特征的关系。方法:回顾性分析术前行^(18)F-FDG PET-CT扫描且经病理学确诊为浸润性导管癌的40个病灶,测量最大标准摄取值(SUVmax)、平均标准摄取值(SUVmean)、肿瘤代谢体积(MTV)并计算糖酵解总量(TLG)。结果:40个浸润性导管癌中,孕激素受体(PR)(-)组SUVmax和MTV高于PR(+)组,雌激素受体(ER)(-)组SUVmax、SUVmean、MTV和TLG均高于ER(+)组,表皮生长因子受体-2(HER-2)(-)组MTV低于HER-2(+)组,T1~T2期肿瘤的SUVmax、SUVmean、TLG和MTV均小于T3~T4期,有腋窝淋巴结转移病例的SUVmax、SUVmean和TLG均高于无腋窝淋巴结转移病例(P<0.05~P<0.01)。原发灶的SUVmax、MTV与Ki-67表达呈正相关关系(P<0.01)。腋窝淋巴结的SUVmax与原发灶Ki-67表达呈正相关关系(P<0.01)。结论:^(18)F-FDG PET-CT代谢参数能够评估乳腺浸润性导管癌的临床病理特征。Objective:To evaluate the relationship between the metabolic parameters of ^(18)F-deoxyglucose positron emission computed tomography(^(18)F-FDG PET-CT) and clinical and pathological characteristics of invasive ductal carcinoma of breast.Methods:The clinical data of 40 primary lesions of invasive ductal carcinoma of breast diagnosed by pathology and scanned by ^(18)F-FDG PET-CT before operation were retrospectively analyzed.The max of standardized uptake value(SUVmax),mean of standardized uptake value(SUVmean) and metabolic tumor volume(MTV) of lesions were measured,and the total lesion glycolysis(TLG) of lesions were calculated.Results:The SUVmax and MTV of the PR(-) group were higher than those of the PR(+) group.The SUVmax,SUVmean,TLG and MTV of the ER(-) group were higher than those of the ER(+) group.The MTV of the HER-2(-) group was lower than that of HER-2(+) group,the SUVmax,SUVmean,TLG and MTV of the stage T1-T2 tumors were less than those of the stage T1-T2 tumors,and the SUVmax,SUVmean,TLG and MTV in cases with axillary lymph node metastasis were higher than those in cases without axillary lymph node metastasis(P<0.05 to P<0.01).The SUVmax and MTV were positively correlated with the expression of Ki-67 in primary lesions(P<0.01).The SUVmax of axillary lymph nodes was positively correlated with the expression of Ki-67 in the primary lesions(P<0.01).Conclusions:The ^(18)F-FDG PET-CT metabolic parameters can evaluate the biological and clinical characterstics of invasive ductal carcinoma of breast.

关 键 词：乳腺肿瘤 体层摄影术 正电子发射计算机断层扫描 脱氧葡萄糖 

分 类 号：R737.9[医药卫生—肿瘤]