难治性胃食管反流病发病机制研究进展  

Progress in research of pathogenesis of refractory gastroesophageal reflux disease

作　　者：齐梅 周悦 周宇轩 方盛泉[1] Mei Qi;Yue Zhou;Yu-Xuan Zhou;Sheng-Quan Fang(Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200080,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院,上海市200080

出　　处：《世界华人消化杂志》2022年第17期769-774,共6页World Chinese Journal of Digestology

基　　金：上海市中医药三年行动计划重点项目,No.ZY(2021-2023)-0302;上海市卫健委临床专项,No.202140171;上海市自然基金面上项目,No.20ZR1459300。

摘　　要：难治性胃食管反流病(refractory gastroesophageal reflux disease,rGERD)是一种发病因素繁多,机制复杂,发病率逐年攀升的临床常见疾病.目前认为其发病机制多与食管内因素以及食管外因素密切相关.对rG ERD机制深入研究有助于该病的诊断以及治疗,本文通过文献检索,在总结rGERD发病机制研究现状基础上提出对该病的思考及展望,以期为rG ERD发病机制的深入研究提供思路.Refractory gastroesophageal reflux disease(rGERD) is a common clinical disease with many pathogenic factors,complex mechanisms,and increasing incidence.At present,scholars believe that the pathogenesis of rGERD is closely related to intra-and extra-esophageal factors.Elucidating the mechanism of rGERD can contribute to the diagnosis and treatment of the disease.This paper summarizes the current progress in the research of the pathogenesis of rGERD,and puts forward our own thoughts and prospects for the disease,in order to provide ideas for the in-depth study of the pathogenesis of rGERD.

关 键 词：难治性胃食管反流 发病机制 食管内因素 食管外因素 

分 类 号：R571[医药卫生—消化系统]