HBV阳性肝癌患者DCP、AFP、AFP-L3与肝功能状态相关性研究  

Correlation analysis of DCP,AFP and AFP-L3 and liver function status in patients with HBV positive hepatoma

作　　者：靳克俭 潘新波[1] JIN Kejian;PAN Xinbo(Institute of Liver Diseases,the Second People′s Hospital of Lanzhou,Lanzhou,Gansu 730046,China)

机构地区：[1]甘肃省兰州市第二人民医院肝病研究所,甘肃兰州730046

出　　处：《检验医学与临床》2022年第17期2379-2381,共3页Laboratory Medicine and Clinic

基　　金：甘肃省兰州市科技计划项目(2022-2D-17)。

摘　　要：目的探讨乙型肝炎病毒(HBV)阳性肝癌患者血清中异常凝血酶原(DCP)、甲胎蛋白异质体(AFP-L3)和甲胎蛋白(AFP)与肝功能状态的相关性。方法采用回顾性分析法,选取2020年6月到2021年6月在该院接受治疗的HBV阳性肝癌患者100例作为研究对象,将这100例患者按照肝功能损伤程度分为肝功能正常组(50例)和肝功能异常组(50例),分别检测两组患者的DCP、AFP和AFP-L3水平,采用Pearson相关进行相关性分析。结果肝功能异常组患者的DCP、AFP和AFP-L3水平高于肝功能正常组(P<0.05);DCP、AFP和AFP-L3检测肝功能异常的灵敏度分别为77.65%、68.26%和61.53%,特异度分别为89.38%、86.58%和79.86%,当DCP、AFP和AFP-L3联合检测时,其灵敏度可提高到94.32%。Pearson相关分析结果显示,HBV阳性肝癌患者DCP、AFP-L3和AFP水平与肝功能异常均呈正相关(P<0.05)。结论HBV阳性肝癌患者DCP、AFP和AFP-L3水平与肝功能异常均呈正相关,三者可作为检测HBV阳性肝癌患者肝功能状态的辅助诊断指标,对进一步制订治疗计划具有指导意义。此外,DCP、AFP和AFP-L3联合检测可提高对HBV阳性肝癌患者肝功能状态的诊断价值。Objective To investigate the correlation between abnormal prothrombin(DCP),alpha fetoprotein heterogeneity(AFP-L3)and alpha fetoprotein(AFP)and liver function status in serum of hepatitis B virus(HBV)-positive patients with liver cancer.Methods Totally 100 HBV-positive patients with liver cancer who were treated in the hospital from June 2020 to June 2021 were selected as the research objects by retrospective analysis.These 100 patients were divided into normal liver function group(50 cases)and abnormal liver function group(50 cases)according to the degree of liver function damage.The levels of DCP,AFP and AFP-L3 in the two groups were detected respectively.Pearson correlation analysis were used for correlation analysis.Results The levels of DCP,AFP and AFP-L3 in the abnormal liver function group were significantly higher than those in the normal liver function group(P<0.05).The detection sensitivity of DCP,AFP and AFP-L3 in abnormal liver function group were 77.65%,68.26%and 61.53%,respectively,and the specificity were 89.38%,86.58%and 79.86%,respectively.The sensitivity of combined detection of DCP,AFP and AFP-L3 could be increased to 94.32%.The results of Pearson correlation analysis showed that DCP,AFP-L3 and AFP levels of HBV-positive patients with liver cancer positively correlated with liver function abnormalities(P<0.05).Conclusion The levels of DCP,AFP and AFP-L3 in HBV-positive patients with liver cancer positively correlate with abnormal liver function.They could be used as auxiliary diagnostic indicators to detect the status of liver function in HBV-positive patients with liver cancer,and have guiding significance for further treatment planning.In addition,the combined detection of DCP,AFP and AFP-L3 could improve the diagnostic value of liver function status in HBV-positive patients with liver cancer.

关 键 词：肝癌 乙型肝炎病毒 异常凝血酶原 甲胎蛋白 甲胎蛋白异质体 肝功能 

分 类 号：R735.7[医药卫生—肿瘤]