孕早期稽留流产绒毛细胞遗传学分析  

Cytogenetic analysis of villus in missed abortion in first trimester

作　　者：孙诗雨 陈小丽[1] 王晓娅 刘彩玉[1] 蓝信强 SUN Shiyu;CHEN Xiaoli;WANG Xiaoya;LIU Caiyu;LAN Xinqiang(Department of Medical Genetics,Weihai Second Municipal Hospital Affiliated to Qingdao University/Weihai Maternal and Child Health Hospital,Weihai,Shandong 264200,China;Dongguan Yi′an Technology Co.,Ltd.,Dongguan,Guangdong 523662,China)

机构地区：[1]青岛大学附属威海市立第二医院/山东省威海市妇幼保健院医学遗传科,山东威海264200 [2]广东省东莞市宜安科技股份有限公司,广东东莞523662

出　　处：《检验医学与临床》2022年第17期2385-2388,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨绒毛细胞染色体核型对孕早期稽留流产的作用。方法选取2020年1月至2021年6月于该院行清宫术和绒毛染色体检查的166例孕早期稽留流产孕妇为研究对象,采用培养法制备绒毛细胞染色体标本并进行染色体核型分析,分析孕早期稽留流产孕妇的年龄、胎儿性别、孕产史与染色体核型异常的关系。结果166例孕妇的稽留流产绒毛标本中,培养成功159例,其中绒毛染色体核型正常54例,核型异常105例,染色体数目异常98例,染色体结构异常7例。核型异常主要有16-三体18例、22-三体12例和三倍体16例。染色体核型异常主要集中在35~39岁的孕妇中。结论孕早期稽留流产绒毛染色体核型异常较为常见,且主要为染色体数目异常,且染色体畸变与孕妇年龄有关。通过对绒毛染色体核型分析可为孕妇的再次妊娠提供诊疗依据。Objective To investigate the effect of villous cell karyotype on missed abortion in the first trimester.Methods From January 2020 to June 2021,166 pregnant women who underwent uterine evacuation and villous chromosome examination for missed abortion in the first trimester of the hospital were selected as the research objects.Chromosome specimens of villus were prepared by culture method and karyotype analysis was carried out.The relationship between age,fetal gender,maternal history and abnormal karyotype of pregnant women with missed abortion in the first trimester was analyzed.Results Among 166 pregnant women′s villus specimens from missed abortion,159 were successfully cultured,including 54 cases with normal karyotype,105 cases with karyotype abnormal,98 cases with abnormal chromosome number and 7 cases with abnormal chromosome structure.The karyotype abnormal mainly included 18 cases of trisomy 16,12 cases of trisomy 22 and 16 cases of triploidy.Chromosomal karyotype abnormal were mainly concentrated in pregnant women aged 35 to 39 years.Conclusion Chromosomal karyotype abnormalities in villus are common in early missed abortions,and are mainly abnormal in the number of chromosomes.Chromosomal aberrations are related to maternal age.The analysis of the villus karyotype can provide the basis for diagnosis and treatment of pregnant women′s re-pregnancy.

关 键 词：稽留流产 绒毛 染色体异常 核型 年龄 

分 类 号：R715.5[医药卫生—妇产科学]