调中化湿汤治疗功能性便秘的临床效果及其对患者血清胃肠激素水平的影响  

Clinical effect of Tiaozhong Huashi Decoction for the treatment of functional constipation and its influence on the levels of serum gastrointestinal hormones in patients

作　　者：赵一娜[1] 黄晓燕[1] 陈广文[1] 韦金秀 杨成宁 刘莉[1] 陈雅璐 刘礼剑[1] ZHAO Yi-na;HUANG Xiao-yan;CHEN Guang-wen;WEI Jin-xiu;YANG Cheng-ning;LIU Li;CHEN Ya-lu;LIU Li-jian(Department of Spleen and Stomach Disease,the First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,Guangxi,China)

机构地区：[1]广西中医药大学第一附属医院脾胃病科,广西南宁市530023

出　　处：《广西医学》2022年第14期1619-1623,共5页Guangxi Medical Journal

基　　金：国家自然科学基金(82160877);广西科技计划(桂科AD19245168);中医药循证能力建设项目(2019XZZX-XH003)。

摘　　要：目的 分析自拟方调中化湿汤治疗功能性便秘的临床效果,以及对患者血清胃动素、血管活性肠肽(VIP)、5-羟色胺水平的影响。方法 将90例功能性便秘患者随机分为观察组和对照组,每组45例。分别给予观察组调中化湿汤、对照组枸橼酸莫沙必利片治疗,疗程均为4周。比较两组患者的中医证候疗效,治疗前后的中医症状积分、便秘患者生存质量量表(PAC-QOL)评分,以及治疗前后血清胃动素、VIP、5-羟色胺水平。结果 治疗后,观察组的中医证候疗效优于对照组(P<0.05)。治疗后,两组各项中医症状积分、PAC-QOL评分均较治疗前下降,血清胃动素、5-羟色胺水平均高于治疗前,血清VIP水平均低于治疗前,并且观察组上述指标均优于对照组(均P<0.05)。结论 与常规西药相比,调中化湿汤不仅可更有效地改善功能性便秘患者的临床症状,还能更好地提高患者的生活质量,其机制可能与上调血清胃动素和5-羟色胺水平、下调VIP水平有关。Objective To analyze the clinical effect of self-made prescription Tiaozhong Huashi Decoction for the treatment of functional constipation, and its influence on levels of serum motilin, vasoactive intestinal peptide(VIP), and 5-hydroxytryptamine. Methods Ninety patients with functional constipation were randomly assigned to observation group or control group, with 45 cases in each group. The observation group was treated with Tiaozhong Huashi Decoction, while the control group was treated with Mosapride Citrate Tablets. Both groups received a treatment course of 4 weeks. The clinical efficacy of Traditional Chinese Medicine syndrome, the pre-and post-treatment Traditional Chinese Medicine symptom score, the Patient Assessment of Constipation Quality of Life(PAC-QOL) score, and levels of serum motilin, VIP, and 5-hydroxytryptamine were compared between the two groups.Results After treatment, the observation group yielded superior efficacy of Traditional Chinese Medicine syndrome to compared with the control group(P<0.05). After treatment, both groups exhibited declines of various Traditional Chinese Medicine syndrome scores, and of PAC-QOL score in the comparison of before treatment, and higher levels of serum motilin, VIP, and 5-hydroxytryptamine as compared with before treatment, whereas lower level of serum VIP in the comparison of before treatment, as well as the observation group interpreted superior aforesaid indices to compared with the control group(all P<0.05). Conclusion As compared with routine Western Medicine, Tiaozhong Huashi Decoction can not only more effectively ameliorate the clinical symptoms of patients with functional constipation, but also preferably improve the patients′ quality of life, and its mechanism may be related to the up-regulation of serum motilin and 5-hydroxytryptamine levels, and to the down-regulation of VIP level.

关 键 词：功能性便秘 调中化湿汤 中医疗效 生活质量 胃肠激素 

分 类 号：R574.62[医药卫生—消化系统]