重金属失衡与帕金森病的相关性研究进展  

Progress of research on the correlation between heavy metal imbalance and Parkinson’s disease

作　　者：李颖[1] 张英莹 贺志会 凌丽[1] LI Ying;ZHANG Yingying;HE Zhihui;LING Li(Affiliated Hospital of Hebei University,Baoding 071000,China)

机构地区：[1]河北大学附属医院,河北保定071000

出　　处：《中国实用神经疾病杂志》2022年第8期1006-1011,共6页Chinese Journal of Practical Nervous Diseases

基　　金：2021年度河北省医学科学研究课题计划(编号:20210704);2021年度院内重点科研基金项目(编号:2021Z005)。

摘　　要：帕金森病(Parkinson’s disease,PD)是一种好发于老年人的神经变性病。在PD病例中,约90%的病例无法用遗传背景解释,因此,环境因素在PD中起十分重要的作用,其中重金属在神经系统中发挥多种生理和病理作用,人体必需重金属元素失衡及有毒重金属元素过量积累会导致氧化应激、线粒体功能障碍、α-突触核蛋白形成,从而导致多巴胺能神经元的损伤。本文对这些重金属如何影响大脑生理及病理过程,以及在进行重金属与PD的相关性研究时生物标志物的选择问题作一综述。Parkinson’s disease(PD)is a neurodegenerative disease that predominantly affects the elderly.Approximately 90%of PD cases cannot be explained by genetic background,therefore,environmental factors play a very important role in PD.Among them,heavy metals play various physiological and pathological roles in the ner⁃vous system,and imbalance of essential heavy metal elements and excessive accumulation of toxic heavy metal ele⁃ments can lead to oxidative stress,mitochondrial dysfunction,andα-synaptic nuclear protein formation,resulting in dopaminergic neuronal damage.In this review,we explore how these heavy metals affect brain physiological and path⁃ological processes and the selection of biomarkers when conducting studies on the relevance of heavy metals to PD.

关 键 词：帕金森病 重金属 生物样本 必需微量元素 有毒微量元素 危险因素 

分 类 号：R742.5[医药卫生—神经病学与精神病学]