5-羟甲基胞嘧啶在神经退行性疾病中的作用研究进展  

Study on 5-hydroxymethyl cytosine in neurodegenerative diseases

作　　者：李小桃 朱爱琴[2] LI Xiaotao;ZHU Aiqin(Graduate School of Qinghai University,Xining 810000,China;Qinghai Provincial People’s Hospital,Xining 810007,China)

机构地区：[1]青海大学研究生院,青海西宁810000 [2]青海省人民医院,青海西宁810007

出　　处：《中国实用神经疾病杂志》2022年第7期895-898,共4页Chinese Journal of Practical Nervous Diseases

基　　金：青海省卫生健康系统重点课题(编号:2021-wjzd-03);青海省科技厅重点研发与转化计划(编号:2021-SF-133)。

摘　　要：神经退行性疾病是一种慢性进行性疾病,包括阿尔茨海默病(Alzheimer’s disease,AD)、帕金森病(Parkinson’s disease,PD)、多系统萎缩(multiple system atrophy,MSA)、亨廷顿病(Huntington disease,HD)等,其病因目前尚不清楚。近年研究表明,5-羟甲基胞嘧啶(5-hydroxymethylcytosine,5hmC)可能参与了AD、PD、HD等多种神经退行性疾病的发生机制。本文就近年来5hmC与表观遗传学的关系、TET家族蛋白及5hmC在神经退行性疾病中的作用进行综述。Neurodegenerative disease is a chronic progressive disease.Including Alzheimer’s disease(AD),Parkinson’s disease(PD),multiple system atrophy(MSA),Huntington Disease(HD),etc.The etiology of 5-hydroxymethylcytosine(5hmC)is still unclear.Recent studies have shown that 5-hydroxymethylcytosine(5hmC)may be involved in the pathogenesis of various neurodegenerative diseases such as AD,PD and HD.This article reviews the relationship between 5hmC and epigenetics,TET family proteins and the role of 5hmC in neurodegenerative diseases in recent years.

关 键 词：神经退行性疾病 阿尔茨海默病 帕金森病 多系统萎缩 亨廷顿病 5-羟甲基胞嘧啶 TET家族蛋白 表观遗传学 

分 类 号：R74[医药卫生—神经病学与精神病学]