Regulation of transforming growth factor-β signaling as a therapeutic approach to treating colorectal cancer  

作　　者：Jana Maslankova Ivana Vecurkovska Miroslava Rabajdova Jana Katuchova Milos Kicka Michala Gayova Vladimir Katuch 

机构地区：[1]Department of Medical and Clinical Biochemistry,Faculty of Medicine,Pavol Jozef Safarik University in Kosice,Kosice 04011,Slovakia [2]First Department of Surgery,Medical Faculty of Safarik University,Kosice 04011,Kosicky kraj,Slovakia [3]Department of Burns and Reconstructive Surgery,Medical Faculty at Safarik University and University Hospital,Kosice 04011,Slovakia [4]Department of Neurosurgery,Medical Faculty at Safarik University and University Hospital,Kosice 04011,Slovakia

出　　处：《World Journal of Gastroenterology》2022年第33期4744-4761,共18页世界胃肠病学杂志（英文版）

摘　　要：According to data from 2020,Slovakia has long been among the top five countries with the highest incidence rate of colorectal cancer(CRC)worldwide,and the rate is continuing to rise every year.In approximately 80%of CRC cases,allelic loss(loss of heterozygosity,LOH)occurs in the long arm of chromosome 18q.The most important genes that can be silenced by 18q LOH or mutations are small mothers against decapentaplegic homolog(SMAD)2 and SMAD4,which are intracellular mediators of transforming growth factor(TGF)-βsuperfamily signals.TGF-βplays an important role in the pro-oncogenic processes,including such properties as invasion,epithelial-mesenchymal transition(commonly known as EMT),promotion of angiogenesis,and immunomodulatory effects.Several recent studies have reported that activation of TGF-βsignaling is related to drug resistance in CRC.Because the mechanisms of drug resistance are different between patients in different stages of CRC,personalized treatment is more effective.Therefore,knowledge of the activation and inhibition of factors that affect the TGF-βsignaling pathway is very important.

关 键 词：Small mothers against decapentaplegic homologs Transforming growth factor-beta Colorectal cancer MARKER Signaling pathway 

分 类 号：R735.34[医药卫生—肿瘤]