血清外泌体微小RNA在肺癌中的临床应用进展  

Research progress on clinical application for microRNA of serum exosomes in lung cancer

作　　者：朱星成 李博[3] 孙继芹 付绍祥 Zhu Xingcheng;Li Bo;Sun Jiqin;Fu Shaoxiang(Department of Clinical Laboratory,Qujing Second People's Hospital,Qujing 655000,Yunnan,China;Department of Clinical Laboratory,Nanfang Hospital,of Southern Medical University,Guangzhou 510515,Guangdong,China;Department of Nuclear Medicine,Qujing Second People's Hospital,Qujing 655000,Yunnan,China)

机构地区：[1]曲靖市第二人民医院检验科,云南曲靖655000 [2]曲靖市第二人民医院核医学科,云南曲靖655000 [3]南方医科大学南方医院检验科,广东广州510515

出　　处：《实用检验医师杂志》2022年第2期212-215,共4页Chinese Journal of Clinical Pathologist

摘　　要：外泌体是由各种细胞分泌的细胞外囊泡(EVs)中的一种类型,其携带的核酸、蛋白质、脂质和其他生物活性分子具有细胞特异性。由于其在细胞间通信中的作用,血清外泌体可作为一种新兴的肺癌早期生物标志物。该文从肺癌与微小RNA(miRNA)的关系、外泌体的特征、肺癌与血清外泌体的关系、外泌体来源的miRNA含量、潜在靶基因及其在肺癌中受miRNA影响的信号通路等方面进行综述,评价外泌体miRNA对肺癌诊疗及疗效评估的临床价值,并对未来发展趋势进行展望。The extracellular vesicles(EVs)can be secreted by a variety of cells,and exosome is a type of EVs,carrying cell-specific cargo of nucleic acids,proteins,lipids and other biologically active molecules.Molecular components of serum-derived exosomes are a kind of emerging biomarkers for early detection of lung cancer,due to its role in intercellular communication.In this review,lung cancer and microRNA(miRNA),exosome characteristics,lung cancer and serum exosomes,miRNA content,potential target genes and signaling pathways affected by miRNA present in lung cancer signatures of serum-derived exosomes are presented and discussed,meanwhile,its clinical application is evaluated for diagnosis and treatment,and assessment of therapeutic effect in lung cancer and the brief outlook of its development are made.

关 键 词：生物标志物 外泌体 细胞外囊泡 肺癌 微小RNA 

分 类 号：R734.2[医药卫生—肿瘤] R730.43[医药卫生—临床医学]