新型齐墩果酸-1,2,3-三氮唑衍生物的设计、合成及活性研究  

Design,Synthesis and Activity Studies of Novel Oleanolic Acid-1,2,3-triazole Derivatives

作　　者：杨东鑫 王友德 张丽颖[1] YANG Dong-xin;WANG You-de;ZHANG Li-ying(Key Laboratory of Research and Exploiture for New Drugs of Chinese Materia Medicine,Institute of Chinese Materia Medica,Chengde Medical College,Hebei Chengde 067000,China)

机构地区：[1]河北省中药研究与开发重点实验室,承德医学院中药研究所,河北承德067000

出　　处：《广州化工》2022年第16期33-34,38,共3页GuangZhou Chemical Industry

基　　金：河北省自然科学基金(No:H2021406034)。

摘　　要：以齐墩果酸为原料,经过取代、酰化、环加成和还原等反应,设计并合成了两种新型齐墩果酸-1,2,3-三氮唑衍生物,并通过HepG2细胞葡萄糖消耗实验测定其生物活性。目标化合物的化学结构均经过IR、NMR和MS确证。生物活性测试结果表明:目标化合物7与目标化合物8对HepG2细胞的葡萄糖消耗均有促进作用,其中,目标化合物7具有显著的促进作用,为解决高血糖问题提供了有价值的线索。Two novel oleanolic acid-1,2,3-triazole derivatives were designed and synthesized from oleanolic acid through substitution,acylation,cycloaddition and reduction.Their biological activities were determined by glucose consumption test of HepG2 cells.The chemical structures of the target compounds were confirmed by IR,NMR and MS.The results of biological activity test showed that both target compound 7 and target compound 8 promoted the glucose consumption of HepG2 cells,among which target compound 7 had a significant promoting effect,which provided a valuable clue to solve the problem of hyperglycemia.

关 键 词：齐墩果酸 1 2 3-三氮唑 HEPG2 葡萄糖消耗 

分 类 号：R914.5[医药卫生—药物化学]