MicroRNAs:protective regulators for neuron growth and development  

作　　者：Zhi-Xuan Ma Zhen Liu Hui-Hui Xiong Zong-Pu Zhou Li-Si Ouyang Fu-Kang Xie Ya-Mei Tang Zhong-Dao Wu Ying Feng 

机构地区：[1]School of Medicine,South China University of Technology,Guangzhou,Guangdong Province,China [2]Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou,Guangdong Province,China [3]Department of Neurology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou,Guangdong Province,China [4]Key Laboratory of Tropical Disease Control,Ministry of Education,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou,Guangdong Province,China

出　　处：《Neural Regeneration Research》2023年第4期734-745,共12页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.81801208(to LSO);Science and Technology Program of Guangzhou,No.202102080053(to YF);Science and Technology Program of Guangzhou,No.202007030001(to YMT);Science and Technology Planning Project of Guangzhou,No.202102020027(to ZL)。

摘　　要：MicroRNAs(miRNAs)play an important regulatory role in neuronal growth and development.Different mi RNAs target different genes to protect neurons in different ways,such as by avoiding apoptosis,preventing degeneration mediated by conditional mediators,preventing neuronal loss,weakening certain neurotoxic mechanisms,avoiding damage to neurons,and reducing inflammatory damage to them.The high expression of mi RNAs in the brain has significantly facilitated their development as protective targets for therapy,including neuroprotection and neuronal recovery.mi RNA is indispensable to the growth and development of neurons,and in turn,is beneficial for the development of the brain and checking the progression of various diseases of the nervous system.It can thus be used as an important therapeutic target for models of various diseases.This review provides an introduction to the protective effects of mi RNA on neurons in case of different diseases or damage models,and then provides reference values and reflections on the relevant treatments for the benefit of future research in the area.

关 键 词：brain damage MIRNA neurodegenerative disorders neuronal apoptosis neuronal protection 

分 类 号：R741[医药卫生—神经病学与精神病学]