甲基化修饰与胶质瘤  

Methylation modification and glioma

作　　者：张旭[1] 曾智[2] 熊晓星[1] Zhang Xu;Zeng Zhi;Xiong Xiaoxing(Department of Neurosurgery,2Department of Pathology,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院神经外科,武汉430060 [2]武汉大学人民医院病理科,武汉430060

出　　处：《中国组织化学与细胞化学杂志》2022年第3期300-304,共5页Chinese Journal of Histochemistry and Cytochemistry

基　　金：国家自然科学基金项目(81870939)。

摘　　要：甲基化修饰是调节遗传信息表达的一种表观遗传方式。近年来,肿瘤细胞甲基化修饰被广泛研究,其在胶质瘤中的作用是神经科学研究的热点。本文就甲基化修饰的特点、甲基化修饰在胶质瘤中的作用及其机制、甲基化对胶质瘤发生、发展、治疗和预后的影响作一综述。Methylation is an epigenetic modification to modulate the expression of genetic information.Methylation modification in tumor cells has been extensively studied in recent years,and its role in glioma is a hotspot in neuroscience research.This article reviews the characteristics of methylation modification,the role and mechanism of methylation modification in glioma,and the impact of methylation on the occurrence,development,treatment and prognosis of glioma.

关 键 词：胶质瘤 甲基化 表观遗传学 机制 

分 类 号：R365[医药卫生—病理学]