对血管性认知功能障碍患者睡眠质量和结构的研究  

The research of sleep quality and structure in patients with vascular cognitive impairment

作　　者：胡玮玮 黄光[2] 王文科 

机构地区：[1]北京市朝阳区双桥医院,北京101100 [2]首都医科大学附属复兴医院,北京100038

出　　处：《首都食品与医药》2022年第16期18-21,共4页Capital Food Medicine

摘　　要：目的监测VCI患者的睡眠质量和睡眠结构,探讨其与认知功能的相关性。方法收集2019年1月-2020年1月北京市朝阳区双桥医院神经内科门收治的81例患者作为VCI组。收集同时期相同年龄范围的32例体检健康志愿者作为对照组。全部研究对象进行认知功能测试,并进行事件相关电位(ERP)检查。同时进行精神状况量表测试。比较两组的认知功能相关指标[MoCA评分、MMSE评分、ERP(P300)波幅和潜伏期、起立-行走计时测试时间]、睡眠质量(PSQI评分、SRSS评分)、睡眠进程、睡眠结构和REM期参数(多导睡眠图,Polysomnography,PSG)。结果①认知功能测试结果:VCI组的MoCA评分、MMSE评分较对照组均降低,P300潜伏期较对照组延长,P300波幅较对照组降低,TUGT用时较对照组延长(P<0.05)。②睡眠状况测试结果:VCI组和对照组的匹兹堡睡眠质量指数量表(PSQI)总分差异有统计学意义(P<0.05)。VCI组和对照组的睡眠状况自评量表(SRSS)评分差异有统计学意义(P<0.05);据多导睡眠图,VCI组较对照组睡眠潜伏期(SL)、觉醒次数(AT)、觉醒时间(ATA)、第1期睡眠比例(S1%)、第2期睡眠比例(S2%)、觉睡比(A/TSA)均增加,而睡眠总时间(TST)、第3期睡眠比例+第4期睡眠比例(S3%+S4%)、快速动眼期(REM)时间及比例、睡眠效率(SE)、睡眠维持率(SMT)均缩短(P<0.05)。③VCI组和对照组的睡眠分期分析结果:VCI组、对照组患者在第1期睡眠比例(S1%)、第2期睡眠比例(S2%)、第3期睡眠比例+第4期睡眠比例(S3%+S4%)、快速动眼期比例(REM%)差异有统计学意义(P<0.05)。④相关性分析结果:P300与MoCA直线相关系数r_(1)为-0.637(P<0.05),TUGT与MoCA直线相关系数r_(2)为-0.732(P<0.05),PSQI与MoCA直线相关系数r_(3)为-0.801(P<0.05),表明P300、TUGT及PSQI与MoCA间有相关性,呈负向变化趋势。PSG与MoCA直线相关系数r_(4)为0.661(P<0.05),表明PSG与MoCA间有相关性,呈正向变化趋势。结论VCI患者认知功�Objective To monitor the sleep quality and sleep structure of patients with VCI and explore its correlation with cognitive function Method 81 patients treated in the Department of Neurology in our hospital from January 2019 to January 2020 were collected as the VCI groqp.32 healthy volunteers of the same age range in the same period were collected as the control group.All subjects underwent cognitive function test and event-related potential(ERP)examination At the same time,mental status scale test was carried out.The cognitive function related[MOCA score,MMSE score,ERP(P300)anplitude and latency,standing walking timing test time],sleep quality PSQI score,SRSS score,sleep process,sleep structure and REM parameters(polysomnography)were compared between the two groups.Results①Cognitive function test results:the MOCA score and WSE score of VCI group were lower than those of the control group,the P300 latency was longer,the P300 anplitude was lower,and the TUGT time was longer than that of the control group(P<0.05).②Results of sleep status test:there viere significant differaxes in the scores of self rating scale for sleep status(SRSS)and Pittsburgh sleep quality index(PSQI)between VCI group and control group(P<0.05);According to polysomnography,conpared with the control group,the sleep latency(SL),the nuiber of arousals(at),the arousal time(ATA),the proportion of sleep in phase 1(S1%),the proportion of sleep in phase 2(S2%)and the sleep to sleep ratio(A/TSA)in VCI grap increased,while the total sleep tine(1ST),the proportion of sleep in phase 3+4(S3%+S4%),the time and proportion of rapid eye movement(REM),sleep efficiency(SE)and sleep maintenance rate(SMI)were shortened(P<0.05).③The results of sleep staging analysis between VCI group and control group:there was significant difference between VCI group and control group in the proportion of stage 1 sleep(Si),stage 2 sleep(S2),stage 3 sleep+stage 4 sleep(S3%+-S4%),and rapid eye movement(REM)(P<0.05).④The results of correlation analysis:the linear correlation c

关 键 词：血管性认知功能障碍 睡眠障碍 多导睡眠图 神经心理学量表 匹兹堡睡眠质量指数量表 

分 类 号：R743[医药卫生—神经病学与精神病学]