小剂量氟尿嘧啶持续静脉输注在晚期大肠癌多线治疗进展后的疗效观察  

Observation on the efficacy of continuous intravenous infusion of low-dose fluorouracil in advanced multiline therapy for advanced colorectal cancer

作　　者：唐冬艳 黄静仪 Tang Dongyan;Huang Jingyi(Tumor area 2 of Kaiping Central Hospital,Jiangmen,Guangdong 529300,China)

机构地区：[1]广东省开平市中心医院,广东江门529300

出　　处：《首都食品与医药》2022年第16期46-49,共4页Capital Food Medicine

摘　　要：目的观察小剂量氟尿嘧啶持续静脉输注在晚期大肠癌中多线治疗的进展及其疗效。方法回顾性分析70例晚期大肠癌患者的临床资料,依据治疗方式的不同分为研究组(n=35)与对照组(n=35),对照组患者采用奥沙利铂治疗,研究组患者采用小剂量氟尿嘧啶与奥沙利铂联合的治疗方式。比较两组患者用药后的毒副反应,各项生命质量评分以及两组患者的治疗效果。结果研究组患者用药后的毒副反应情况明显低于对照组,差异有统计学意义(P<0.05);两组患者治疗前的生命质量评分差异无统计学意义(P>0.05),研究组患者治疗后各项生命质量的评分明显高于对照组,差异有统计学意义(P<0.05),对照组患者治疗后生命质量的各项评分显著高于治疗前,差异有统计学意义(P<0.05),研究组患者治疗后生命质量的各项评分明显高于治疗前,差异有统计学意义(P<0.05);研究组患者的治疗总效果明显高于对照组,差异有统计学意义(P<0.05)。结论对晚期大肠癌多线治疗后的患者采用小剂量氟尿嘧啶持续静脉输注的治疗方式,对患者产生毒副作用较小,利于患者治疗后生命质量水平的提升,治疗的总效果得到显著提高,值得在临床治疗中推广应用。Objective To observe the progress and efficacy of continuous intravenous infusion of low-dose fluorouracil in advanced colorectal cancer.Methods The clinical data of 70 patients with advanced colorectal cancer were retrospectively analyzed.The patients were divided into study group(n=35)and control group(n=35)according to different treatment methods.Patients in the control group were treated with oxaliplatinA combination of low-dose fluorouracil and oxaliplatin was used.The toxicity and side effects of the two groups of patients after treatment,the quality of life scores and the treatment effects of the two groups of patients were conpared.Results The toxic and side effects of the patients in the study group were significantly lower than those in the control group,and the difference was statistically significant(P<O.05).There was no significant difference in the quality of life scores between the two groups before treatment (P>0.05).The scores of life quality after treatment in the study group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).The total treatment effect of the study group was significantly higher than that of the control group.The difference was statistically significant.Significance(P<0.05).Conclusion Patients with advanced colorectal cancer after multiline therapy,a small dose of fluorouracil was used for continuous intravenous infusion,the side effects are minor,it is beneficial to improve the quality of life after treatment,and the total therapeutic effect is significantly improved.Gcnducive to the application in clinical treatment.

关 键 词：小剂量氟尿嘧啶 持续静脉输注 晚期大肠癌 生活质量 

分 类 号：R735.34[医药卫生—肿瘤]