GnRHa化疗期间对卵巢功能保护的临床研究  

Clinical study on the protection of ovarian function during GnRHa chemotherapy

作　　者：陈艳丽[1] 马艳群[1] 方梓羽[1] Chen Yanli;Ma Yanqun;Fang Ziyu(Department of Gynecology,Liuzhou Workers Hospital,Liuzhou 545005,China)

机构地区：[1]柳州市工人医院妇科,广西柳州545005

出　　处：《实用妇科内分泌电子杂志》2022年第7期47-49,共3页Electronic Journal of Practical Gynecological Endocrinology

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费课题(编号Z2016795)。

摘　　要：目的探讨促性腺激素释放激素类似物(GnRHa)对化疗患者卵巢功能保护的临床价值。方法选取60例绝经前妇科恶性肿瘤患者,采用随机数字表法分为研究组(30例,给予GnRHa治疗)与对照组(30例,不给予GnRHa治疗),连续使用6次,治疗结束后均随访观察3个月。比较两组患者治疗前后促黄体生成素、抗缪勒管激素(AHM)、卵泡刺激素水平、月经来潮恢复情况与时间及卵巢功能损伤症状发生率。结果治疗前,两组患者促黄体生成素(8.05±1.26 VS 8.12±1.30 mIU/ml)、AHM(3.95±1.10 VS 4.02±1.07 ng/ml)、卵泡刺激素(5.43±0.95 VS 5.50±0.94 pg/ml)水平比较,差异无统计学意义(P>0.05);治疗结束后研究组患者促黄体生成素(9.59±1.75 VS 15.43±2.59 mIU/ml)、卵泡刺激素(7.26±1.22 VS 10.35±2.45 pg/ml)水平低于对照组,AHM(2.55±0.89 VS 1.43±0.28 ng/ml)水平高于对照组,研究组患者化疗结束后3个月内的月经恢复率(100% VS 70%)高于对照组,月经来潮平均恢复时间短于对照组,卵巢损伤症状总发生率(6.67% VS 40.00%)低于对照组,差异均有统计学意义(P<0.05)。结论GnRHa的卵巢功能保护效果良好确切,可改善患者性激素表达水平,预防卵巢功能损伤的发生。Objective To investigate the clinical value of gonadotropin-releasing hormone analogs(GnRHa)in the protection of ovarian function in patients with chemotherapy.Methods 60 patients with premenopausal gynecological malignant tumors were selected and randomly divided into the study group(30 cases,treated with GnRHa)and the control group(30 cases,not treated with GnRHa).All patients were followed up for 3 months after continuous treatment for 6 times.The levels of luteinizing hormone(luteinizing hormone),anti-Mullerian hormone(AHM),follicle stimulating hormone(FSH),the recovery of menstruation and the incidence of ovarian function injury symptoms before and after treatment were compared between the two groups.Results Before treatment,luteinizing honnone(8.05±1.26 VS 8.12±1.30 mIU/ml),AHM(3.95±1.10 VS 4.02±1.07 ng/ml),follicle stimulating hormone(5.43±0.95 VS 5.50±0.94 pg)There was no significant difference in the level of luteinizing hormone(9.59±1.75 VS 15.43±2.59 mIU/ml)and follicle stimulating hormone(7.26±1.22 VS 10.35±2.45 pg)in the study group After the treatment,the level was lower than the control group,AHM(2.55±0.89 VS 1.43±0.28 ng/ml)level was higher than that of the control group,and the menstrual recovery rate(100% VS 70%)within 3 months after chemotherapy was higher in the study group In the control group,the average recovery time of menstrual cramps was shorter than that in the control group,and the total incidence of ovarian injury symptoms(6.67% VS 40.00%)was lower than that in the control group,with statistical significance(P<0.05).Conclusion GnRHa has a good and definite protective effect on ovarian function,which can improve the expression level of sex hormones in patients and prevent the occurrence of ovarian function damage.

关 键 词：避孕药 恶性肿瘤 化疗 促性腺激素释放激素类似物 

分 类 号：R737.3[医药卫生—肿瘤]