91例结直肠腺瘤患者的膳食钙镁摄入、病理特征及发病因素情况分析  

Analysis of dietary calcium and magnesium intake,pathological characteristics and pathogenic factors in 91 patients with colorectal adenoma

作　　者：赖小练 黄立敏[2] 刘涛[3] 胡远东 李三明 王崇洪 程维霞 李佳星 刘俊 鲁朔焱 李勇[2] LAI Xiaolian;HUANG Limin;LIU Tao;HU Yuandong;LI Sanming;WANG Chonghong;CHENG Weixia;LI Jiaxing;LIU Jun;LU Shuoyan;LI Yong(Guizhou University School of Medicine,Guiyang,Guizhou 550025,China;Department of Oncology,Guizhou Provincial People’s Hospital,Guiyang,Guizhou 550002,China;Guizhou Provincial Center for Disease Control and Prevention,Guiyang,Guizhou 550004,China;Department of Oncology and Gastroenterology,Songtao Miao Autonomous County People’s Hospital,Tongren,Guizhou 554119,China;Department of Central Laboratory,Guizhou Provincial People’s Hospital,Guiyang,Guizhou 550002,China;School of Public Health,Zunyi Medical University,Zunyi,Guizhou 563000,China)

机构地区：[1]贵州大学医学院,贵阳550025 [2]贵州省人民医院肿瘤科,贵阳550002 [3]贵州省疾病预防控制中心,贵阳550004 [4]松桃苗族自治县人民医院肿瘤消化科,贵州铜仁554119 [5]贵州省人民医院中心实验室,贵阳550002 [6]遵义医科大学公共卫生学院,贵州遵义563000

出　　处：《重庆医学》2022年第17期2910-2914,共5页Chongqing medicine

基　　金：国家自然科学基金项目(81960587);贵州省科技计划项目(黔科合支撑[2021]一般067)。

摘　　要：目的了解结直肠腺瘤患者的膳食钙镁摄入水平和病理特征,对结直肠腺瘤患者的发病因素进行分析。方法选取2019年6月至2020年6月松桃苗族自治县人民医院肿瘤消化科91例经病理诊断为结直肠腺瘤患者作为腺瘤组,选取同期88例健康体检者作为对照组。收集两组基本信息和膳食营养信息,对结直肠腺瘤的发病因素进行分析,并对腺瘤患者的息肉分布位置、病理分型情况及膳食钙镁摄入水平进行性别亚组分析。结果腺瘤组男性、年龄≥50岁、吸烟和高血压患者比例高于对照组,差异有统计学意义(P<0.05)。logistic回归分析显示,年龄≥50岁、吸烟是结直肠腺瘤发病的危险因素(P<0.05)。91例腺瘤患者中息肉分布部位较多为直肠、乙状结肠和横结肠,腺瘤患者以管状腺瘤为主,混合性腺瘤次之,绒毛状腺瘤最少。84.6%(77/91)的患者膳食钙摄入量占参考摄入量严重不足及不足,59.3%(54/91)的患者膳食镁摄入量占参考摄入量严重不足及不足。结论年龄≥50岁、有吸烟史且低钙膳食的人群易患结直肠腺瘤。Objective To understand the dietary calcium and magnesium intake levels and pathological characteristics of patients with colorectal adenomas,and to analyze the pathogenic factors of patients with colorectal adenomas.Methods From June 2019 to June 2020,the clinical data of 91 patients with colorectal adenoma diagnosed by pathology and 88 healthy subjects during the same period in the Department of Oncology and Gastroenterology of Songtao Miao Autonomous County People’s Hospital were divided into the adenoma group(n=91)and the control group(n=88).A questionnaire survey was conducted on the two groups to collect basic information and dietary nutrition information.The pathogenesis factors of colorectal adenomas were analyzed,and the distribution of polyps,pathological types and dietary calcium and magnesium intake levels of patients with adenomas were analyzed by gender subgroup.Results The proportions of males,age≥50 years old,smoking and hypertension in adenoma group were higher than those in the control group,the difference was statistically significant(P<0.05).Logistic regression analysis showed that age≥50 years old and smoking history were high risk factors for the incidence of colorectal adenomas(P<0.05).In 91 patients with colorectal adenoma,polyps were mainly distributed in the rectum,sigmoid and transverse colon.The colorectal adenoma patients had mainly tubular adenomas,followed by mixed adenomas and the least villous adenomas.Dietary calcium and magnesium intake was insufficient and severely insufficient for the reference intake in 84.6%(77/91)and 59.3%(54/91)of the patients,respectively.Conclusion People age≥50 years old,with a smoking history and a low-calcium diet are susceptible to colorectal adenomas.

关 键 词：结直肠腺瘤 危险因素 病理分型 病变部位 膳食钙 膳食镁 

分 类 号：R735.3[医药卫生—肿瘤]