胆汁酸G蛋白偶联受体5在非病毒性肝病中的作用  

Role of Takeda G protein-coupled receptor-5 in non-viral liver diseases

作　　者：周群 张华[1] 刘平[1,2] 陈佳美 ZHOU Qun;ZHANG Hua;LIU Ping;CHEN Jiamei(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine/Institute of Liver Diseases,Shanghai University of Traditional Chinese Medicine/Key Laboratory of Liver and Kidney Diseases,Ministry of Education/Shanghai Key Laboratory of Traditional Chinese Clinical Medicine,Shanghai 201203,China;Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai Frontiers Science Center of TCM Chemical Biology,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院,上海市中医药研究院肝病研究所,肝肾疾病病证教育部重点实验室,上海市中医临床重点实验室,上海201203 [2]上海中医药大学交叉科学研究院,上海市中医药化学生物学前沿基地,上海201203

出　　处：《临床肝胆病杂志》2022年第9期2172-2176,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金重点项目(82130120);国家自然科学基金(81973613);上海市青年科技启明星计划项目(19QA1408900)。

摘　　要：非病毒性肝病主要包括非酒精性脂肪性肝病、酒精性肝病、自身免疫性肝病和胆汁淤积性肝病等,近年来患病率呈上升趋势。胆汁酸G蛋白偶联受体5(TGR5)隶属于G蛋白偶联受体超家族,由初级和次级胆汁酸激活,在胆汁酸稳态、基础代谢、能量平衡和减轻炎症反应等方面均发挥重要的调控作用,是多种疾病的潜在治疗靶点。越来越多的证据表明,TGR5可改善肝脏胆汁酸及糖脂代谢,减轻肝脏炎症反应,减少肝脂肪变性,从而发挥保护肝脏的作用。本文就目前TGR5在非病毒性肝病领域中的基础研究进展作一综述,期冀对TGR5的研究发展有所补益。Non-viral liver diseases mainly include nonalcoholic fatty liver disease,alcoholic liver disease,autoimmune liver disease,and cholestatic liver disease,and the prevalence rate of non-viral liver diseases tends to increase in recent years.Takeda G protein-coupled receptor-5(TGR5)belongs to the G protein-coupled receptor superfamily and is activated by primary and secondary bile acids.TGR5 plays an important regulatory role in bile acid homeostasis,basal metabolism,energy balance,and alleviation of inflammatory response and is a potential therapeutic target for many diseases.An increasing number of evidence has shown that TGR5 exerts a protective effect on the liver by improving bile acid and glycolipid metabolism in liver,alleviating liver inflammation,and reducing liver steatosis.This article reviews the recent advances in the basic research on TGR5 in the field of non-viral liver diseases,so as to facilitate the development of the research on TGR5.

关 键 词：胆汁酸G蛋白偶联受体5 非酒精性脂肪性肝病 肝疾病 酒精性 胆管炎 硬化性 

分 类 号：R575[医药卫生—消化系统]