细胞色素P450家族在肝脏代谢相关疾病中的作用  

Role of the cytochrome P450 family in metabolic-associated liver diseases

作　　者：陈玮钰 舒发明 王涵 曹杨港 胡锦 毛德文[2] CHEN Weiyu;SHU Faming;WANG Han;CAO Yanggang;HU Jin;MAO Dewen(Graduate School of Guangxi University of Chinese Medicine,Nanning 530001,China;Department of Hepatology,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China)

机构地区：[1]广西中医药大学研究生院,南宁530001 [2]广西中医药大学第一附属医院肝病科,南宁530023

出　　处：《临床肝胆病杂志》2022年第9期2182-2187,共6页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81960841,82060848);广西自然科学基金创新研究团队项目(2018GXNSFGA281002);广西壮族自治区中青年教师科研基础能力提升项目(2019KY0336)。

摘　　要：细胞色素P450(CYP)家族是体内最重要的药物代谢酶,负责内源性和外源性化合物的代谢。肝脏作为CYP家族表达的主要部位,是药物的代谢中心。近年来,CYP家族在肝脏中的作用受到国内外学者的广泛关注。本文就CYP家族在解剖学、遗传学、基因组学等方面的分布差异,以及在非酒精性脂肪性肝病、酒精性肝病、肝纤维化、肝硬化、肝细胞癌等病理过程中的表达变化作一综述,深入探讨CYP家族介导的酶活性对肝脏代谢相关疾病药物治疗效果的影响,以期为寻找疾病中关键的药物干预靶点和增强临床疗效及安全性提供重要启示。The cytochrome P450(CYP)family is the most important drug-metabolizing enzyme in human body and is responsible for the metabolism of endogenous and exogenous compounds.As the main site of the expression of the CYP family,the liver is the metabolic center of drugs,and in recent years,the role of the CYP family in the liver has attracted wide attention from the scholars in China and globally.This article reviews the distribution differences of the CYP family from the aspects of anatomy,genetics,and genomics,changes in the expression of the CYP family in the pathological processes such as non-alcoholic fatty liver disease,alcoholic liver disease,liver fibrosis,liver cirrhosis,and hepatocellular carcinoma,and the effect of CYP family-mediated enzyme activity on the treatment effect of pharmacotherapy for metabolic-associated liver diseases,in order to provide important enlightenment for identifying key drug intervention targets in diseases and enhancing clinical efficacy and safety.

关 键 词：肝疾病 细胞色素P450酶系统 药代动力学 

分 类 号：R575[医药卫生—消化系统]