碳二亚胺法合成硝唑尼特中产生的主要副产物的分析  

Analysis of Main By-Product Produced in the Synthesis of Nitazoxanide by Carbodiimide Method

作　　者：王汝金[1] 朱建德[1] 王米[1] 王霄旸[1] 杨帆帆[1] 张可煜[1] 费陈忠[1] 刘迎春[1] 王春梅[1] 薛飞群[1] 张丽芳[1] Wang Rujin;Zhu Jiande;Wang Mi;Wang Xiaoyang;Yang Fanfan;Zhang Keyu;Fei Chenzhong;Liu Yingchun;Wang Chunmei;Xue Feiqun;Zhang Lifang(Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics,Ministry of Agriculture and Rural Affairs,Shanghai Veterinary Research Institute,Chinese Academy of Agricultural Sciences,,Shanghai 200241,China)

机构地区：[1]中国农业科学院上海兽医研究所农业农村部兽用化学药物及制剂学重点实验室,上海200241

出　　处：《化学世界》2022年第4期199-202,共4页Chemical World

摘　　要：对硝唑尼特合成中产生的副产物进行结构确证并推测其产生机理。采用高分辨质谱、核磁共振和红外光谱分析等技术对其进行了表征,副产物为2-乙酰氨基-5-硝基噻唑。副产物的结构确证有助于进一步优化硝唑尼特的合成工艺。To confirm the structure of by-product produced in the synthesis of nitazoxanide and speculate its production mechanism,the structure was confirmed by high resolution mass spectrometry,nuclear magnetic resonance and infrared spectroscopy.The chemical structure of by-product was confirmed as 2-acetylamino-5-nitrothiazole.The confirmation of the structure of by-product can helps further optimize the synthesis process of nitazoxanide.

关 键 词：硝唑尼特 副产物 结构鉴定 2-乙酰氨基-5-硝基噻唑 

分 类 号：O656.4[理学—分析化学]