米诺环素经根管途径联合牙周袋内给药治疗牙周牙髓联合病变患者的临床效果  

Clinical Effect of Minocycline Through Root Canal Route Combined with Periodontal Pocket Administration in the Treatment of Patients with Periodontal and Pulpal Combined Lesions

作　　者：孙青 SUN Qing(Department of Stomatology,Jiawang District People′s Hospital,Xuzhou,Jiangsu Province,221011 China)

机构地区：[1]徐州市贾汪区人民医院口腔科,江苏徐州221011

出　　处：《世界复合医学》2022年第8期187-191,共5页World Journal of Complex Medicine

摘　　要：目的探讨米诺环素经根管途径联合牙周袋内给药在牙周牙髓联合病变患者中的临床效果。方法选择2018年5月—2021年2月徐州市贾汪区人民医院收治的牙周牙髓联合病变患者82例作为研究对象,随机数表法分为两组,各41例。对照组采用传统根管治疗,观察组采用米诺环素经根管途径联合牙周袋内给药治疗。治疗后两周评估两组效果,比较两组牙周状况、咀嚼功能、炎性因子及不良反应发生率。结果观察组治疗后PLI(0.78±0.21)分、GI(0.84±0.15)分与BI(1.43±0.25)分均低于对照组,差异有统计学意义(t=9.682、11.733、12.220,P<0.05);观察组治疗后咀嚼效能(90.67±6.74)%和咬合力(131.39±11.52)Ibs均高于对照组,差异有统计学意义(t=7.686、4.289,P<0.05);观察组治疗后TNF-α水平(10.12±2.06)mg/L、IL-6水平(17.34±1.96)ng/L、CRP水平(5.14±1.21)mg/L低于对照组,差异有统计学意义(t=7.859、10.304、7.935,P<0.05);两组治疗期间及治疗后口腔炎、疼痛、出血、皮肤瘙痒、恶心呕吐的发生率分别为4.88%和9.76%,比较差异无统计学意义(χ^(2)=0.180,P>0.05)。结论米诺环素经根管途径联合牙周袋内给药用于牙周牙髓联合病变患者中,有助于改善患者牙周状况,提升咀嚼功能,降低炎性因子水平,且未增加不良反应发生率。Objective To investigate the clinical effect of minocycline through root canal route combined with periodontal pocket administration in patients with periodontal and endodontic lesions.Methods A total of 82 patients with combined periodontal and pulp diseases admitted to Jiawang District People′s Hospital of Xuzhou City from May 2018 to February 2021 were selected as subjects,and divided into two groups by random number table method,with 41 cases in each group.The control group was treated with traditional root canal therapy,while the observation group was treated with minocycline through root canal route combined with periodontal pocket administration.The effects of the two groups were evaluated 2 weeks after treatment,and the periodontal status,masticatory function,inflammatory factors and incidence of adverse reactions were compared between the two groups.Results The PLI(0.78±0.21)points,GI(0.84±0.15)points and BI(1.43±0.25)points scores of the observation group were lower than those of the control group after treatment,and the differences were statistically significant(t=9.682,11.733,12.220,P<0.05);the masticatory efficacy(90.67±6.74)%and the bite force(131.39±11.52)Ibs of the observation group were higher than those of the control group after treatment,and the difference was statistically significant(t=7.686,4.289,P<0.05);after treatment,the level of TNF-α(10.12±2.06)mg/L,the level of IL-6(17.34±1.96)ng/L,and the level of CRP(5.14±1.21)mg/L in the observation group were lower than those in the control group,the difference was statistically significant(t=7.859,10.304,7.935,P<0.05);the incidences of stomatitis,pain,bleeding,skin itching,nausea and vomiting after treatment in the two groups were 4.88%and 9.76%,respectively,there was no statistically significant difference in comparison(χ^(2)=0.180,P>0.05).Conclusion Minocycline is administered through root canal route combined with periodontal pocket in patients with periodontal and endodontic lesions,which is helpful to improve the periodontal cond

关 键 词：米诺环素 根管治疗 牙周牙髓联合病变 牙周状况 咀嚼功能 

分 类 号：R78[医药卫生—口腔医学]