子宫内膜癌术后感染影响因素及外周血Th17/Treg和CA125与YKL-40水平变化  

Influencing factors of postoperative infection and changes of peripheral blood Th17/Treg and CA125 and YKL-40 levels in patients with endometrial cancer

作　　者：赵雪娇 吴颖[2] 赵雪威 张子君 胡清[2] ZHAO Xue-jiao;WU Ying;ZHAO Xue-wei;ZHANG Zi-jun;HU Qing(Shengjing Hospital of China Medical University,Shenyang,Liaoning 110004,China)

机构地区：[1]中国医科大学附属盛京医院第一妇科病房,辽宁沈阳110004 [2]中国医科大学附属盛京医院妇科盆底疾病病房,辽宁沈阳110004 [3]中国医科大学附属盛京医院手术室,辽宁沈阳110004

出　　处：《中华医院感染学杂志》2022年第12期1833-1837,共5页Chinese Journal of Nosocomiology

基　　金：辽宁省自然科学基金资助项目(2019-ZD-0741)。

摘　　要：目的 探究子宫内膜癌术后感染影响因素及外周血辅助性T细胞(Th)17/调节性T细胞(Treg)、糖链抗原125(CA125)、甲壳质酶蛋白40(YKL-40)水平诊断术后感染的临床价值。方法 选取2019年5月-2021年3月中国医科大学附属盛京医院收治的128例子宫内膜癌手术患者为研究对象,根据其术后是否发生感染分为感染组25例,非感染组103例。分析子宫内膜癌术后感染影响因素,绘制受试者工作特征(ROC)曲线,评价外周血Th17/Treg、CA125、YKL-40水平对子宫内膜癌术后感染的诊断价值。结果 多因素Logistic回归分析结果显示,临床分期、手术方式、接受化疗为子宫内膜癌术后感染影响因素(P<0.05);术后1 d,两组患者外周血Th17/Treg、CA125、YKL-40水平均明显升高,且感染组高于非感染组(P<0.05);受试者工作特征(ROC)曲线分析结果显示,术后1 d外周血Th17/Treg、CA125、YKL-40水平联合诊断子宫内膜癌术后感染的曲线下面积(AUC)为0.869,预测效能较高。结论 临床分期、手术方式、接受化疗为子宫内膜癌术后感染影响因素,且子宫内膜癌术后感染患者术后1 d外周血Th17/Treg、CA125、YKL-40水平明显升高,临床检测其水平,有助于早期及时采取针对措施,改善患者预后。OBJECTIVE To investigate the influencing factors of postoperative infection of endometrial cancer and the clinical value of peripheral blood helper T cells(Th17)/regulatory T cells(Treg), sugar chain antigen 125(CA125), and chitinase protein 40(YKL-40) in the diagnosis of postoperative infection. METHODS A total of 128 patients with endometrial cancer who were admitted to Shengjing Hospital Affiliated to China Medical University from May 2019 to Mar. 2021 were selected as the research subjects, and were divided into 25 cases of the infection group and 103 cases of the non-infection group according to whether the postoperative infection occurred or not. The influencing factors of postoperative infection of endometrial cancer were analyzed, the receiver operating(ROC) curve was drawn, and the diagnostic value of peripheral blood Th17/Treg, CA125, and YKL-40 level for postoperative infection of endometrial cancer was evaluated. RESULTS The results of multivariate Logistic regression analysis showed that clinical stage, surgical methods, chemotherapy were the influencing factors for postoperative infection of endometrial cancer(P<0.05). On the 1 st day after operation, the levels of Th17/Treg, CA125, and YKL-40 in peripheral blood of the two groups were significantly increased, which in the infection group was significantly higher than those in the non-infection group(P<0.05);the results of receiver operating characteristic(ROC) curve analysis showed that the area under the curve(AUC) of the combined peripheral blood Th17/Treg, CA125 and YKL-40 levels at 1 day after surgery for the diagnosis of postoperative infection in endometrial cancer was 0.869, with high predictive power. CONCLUSION Clinical stage, surgical method, and receiving chemotherapy were the influencing factors for postoperative infection of endometrial cancer, and the levels of peripheral blood Th17/Treg, CA125, and YKL-40 in patients with postoperative infection in endometrial cancer were significantly increased on the 1 st day after surgery, and cli

关 键 词：子宫内膜癌 感染 预后 辅助性T细胞/调节性T细胞 糖链抗原125 甲壳质酶蛋白40 

分 类 号：R737.33[医药卫生—肿瘤]