女性双相障碍抑郁发作与抑郁症患者T波峰-末间期变化与临床症状的关系  

Relationship between T wave peak-end interval changes and clinical symptoms in female patients with depressive episode of bipolar disorder and depression

作　　者：王亚萍 刘明艳 张晶[2] Wang Yaping;Liu Mingyan;Zhang Jing(Department of Electrocardiography,Yangzhou Wutaishan Hospital,Yangzhou City,Jiangsu Province,225003,China;Department of Cardiovascular Medicine,Subei People's Hospital,Yangzhou City,Jiangsu Province,225001,China)

机构地区：[1]江苏省扬州五台山医院心电图室,江苏省扬州市225003 [2]苏北人民医院心内科,江苏省扬州市225001

出　　处：《现代电生理学杂志》2022年第3期138-143,共6页Journal of Modern Electrophysiology

基　　金：江苏省卫生健康委科研课题(Z2018032);江苏省扬州五台山医院2020年度院课题经费资助(王亚萍WTS2020007)。

摘　　要：目的:探讨心电图T波峰-末间期(Tp-Te)、Tp-Te/QT比值与女性双相障碍抑郁发作和抑郁症临床症状间的关系。方法:选取2020年9月至2022年4月就诊于江苏省扬州五台山医院的女性双相障碍抑郁发作患者(双相抑郁组,n=47)、抑郁症患者(抑郁症组,n=48)和健康志愿者(对照组,n=47)为研究对象。测定Tp-Te间期、QT间期、Tp-Te/QT比值,采用密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、病人自杀风险评分和病人冲动风险评分对患者进行临床症状评估。各组Tp-Te间期值、Tp-Te/QT比值与各量表评分进行相关性分析。结果:3组间Tp-Te间期和Tp-Te/QT比值比较,差异有统计学意义(P<0.001),双相抑郁组和抑郁症组Tp-Te间期和Tp-Te/QT比值显著高于对照组(P<0.01),抑郁症组Tp-Te间期和Tp-Te/QT比值高于双相抑郁组(P<0.05)。与对照组比较,双相抑郁组和抑郁症组HAMD、HAMA、自杀风险评分和冲动风险评分差异有统计学意义(P<0.01)。双相抑郁组和抑郁症组HAMD、HAMA和自杀风险评分差异无统计学意义(P>0.05),而冲动风险评分差异有统计学意义(P<0.05)。双相抑郁组和抑郁症组Tp-Te间期、Tp-Te/QT比值与HAMD和HAMA评分呈正相关(P均<0.05)。结论:女性双相障碍抑郁发作和抑郁症患者Tp-Te间期、Tp-Te/QT比值显著高于正常水平,并与临床症状严重程度有关。Objective:To investigate the relationship between T wave peak-end interval(Tp-Te)changes and clinical symptoms in female patients with depressive episode of bipolar disorder and depression.Methods:Forty-seven female patients with depressive episode of bipolar disorder(bipolar depression group),forty-eight patients with depression(depression group)and forty-seven healthy volunteers(control group)in Yangzhou Wutaishan Hospital from September 2020 to April 2022 were selected as subjects.Tp-Te interval,QT interval,TP-Te/QT ratio of electrocardiogram were measured,and clinical symptoms were evaluated by Hamilton depression rating scale(HAMD),Hamilton anxiety scale(HAMA),patient suicide risk score and patient impulsivity risk score.The correlation between Tp-Te interval,TP-Te/QT ratio and scores of each scale was analyzed.Results:The Tp-Te interval and Tp-Te/QT ratio among the three groups were significantly different(P<0.001).The Tp-Te interval and Tp-Te/QT ratio were significantly higher in the bipolar depression group and depressive group than those in the control group(P<0.01).The Tp-Te interval and Tp-Te/QT ratio were higher in the depression group than those in the bipolar depression group(P<0.05).Compared with the control group,there were statistically significant differences in HAMD,HAMA,suicide risk score and impulsivity risk score in the bipolar depression group and depressive group(P<0.01).There were no statistically significant differences in HAMD,HAMA and suicide risk scores between bipolar depression group and depressive group(P>0.05),but there were statistically significant differences in impulsivity risk scores(P<0.05).Tp-Te interval,TP-Te/QT ratio were positively correlated with HAMD and HAMA scores in the bipolar depressive group and depressive group(all P<0.05).Conclusion:The Tp-Te interval and Tp-Te/QT ratio were significantly higher than normal levels in female patients with depressive episode of bipolar disorder and depression,and were related to the severity of clinical symptoms.

关 键 词：双相型障碍 抑郁障碍 心电描记术 T波峰-末间期 

分 类 号：R749.4[医药卫生—神经病学与精神病学]