脑动脉狭窄程度联合血清Tau蛋白、Aβ和VILIP-1检测对老年认知功能障碍的预测价值  

Predictive value of cerebral artery stenosis combined with serum Tau protein,Aβ and VILIP-1 in elderly cognitive impairment

作　　者：胡金雅 孟祥安 李艳丽 王杰 李娜 穆斌 HU Jinya;MENG Xiangan;LI Yanli(Hebei PetroChina Central Hospital,Langfang 065000,China)

机构地区：[1]河北中石油中心医院,河北廊坊065000

出　　处：《中风与神经疾病杂志》2022年第8期709-712,共4页Journal of Apoplexy and Nervous Diseases

基　　金：2020年廊坊市科学技术研究与发展计划项目(2020013094)。

摘　　要：目的探讨脑动脉狭窄程度联合血清Tau蛋白、β-淀粉样蛋白(Aβ)和视锥样蛋白-1(VILIP-1)检测对老年轻度认知功能障碍(MCI)的预测价值。方法选取2020年7月-2021年12月在我院治疗的老年MCI患者80例(MCI组),同时选取阿尔兹海默症(AD)患者80例(AD组)和健康体检者80例(健康组),比较3组血清Tau蛋白、Aβ和VILIP-1水平,同时分析MCI组和AD组MMSE评分、MOCA评分、ADL评分、脑动脉狭窄程度等差异。结果MCI组血清Tau蛋白高于健康组(P<0.05),Aβ低于健康组(P<0.05),VILIP-1高于健康组(P<0.05),低于AD组(P<0.05)。MCI组MMSE评分和MOCA评分高于AD组(P<0.05)。MCI组、AD组VILIP-1水平与MMSE评分、MOCA评分呈负相关(P<0.05)。MCI组大脑后动脉狭窄率低于AD组(P<0.05)。大脑后动脉狭窄率联合VILIP-1水平预测MCI的ROC曲线下面积为0.852,高于大脑后动脉狭窄率、VILIP-1单独预测(P<0.05)。结论大脑后动脉狭窄率联合VILIP-1水平在预测老年MCI方面有较好的应用价值。Objective To investigated the predictive value of cerebral artery stenosis combine with serum Tau protein,β-amyloid(Aβ)and cone-like protein-1(VILIP-1)detection in elderly patients with mild cognitive impairment(MCI).Methods A total of 80 elderly MCI patients(MCI group)who were treated in our hospital from July 2020 to December 2021 were selected,80 Alzheimer’s disease(AD)patients(AD group)and 80 healthy people(Healthy group),the serum Tau protein,Aβand VILIP-1 levels were compared among the three groups,and the differences in the MMSE score,MOCA score,ADL score,and cerebral artery stenosis between the MCI group and the AD group were also analyzed.Results Serum Tau protein in MCI group was higher than healthy group(P<0.05).A was lower than healthy group(P<0.05),VILIP-1 was higher than healthy group(P<0.05),but lower than AD group(P<0.05).The MMSE score and MOCA score in the MCI group were higher than AD group(P<0.05).The level of VILIP-1 in MCI group and AD group was negatively correlated with MMSE score and MOCA score(P<0.05).The rate of posterior cerebral artery stenosis in the MCI group was lower AD group(P<0.05).The area under the ROC curve of the posterior cerebral artery stenosis rate combine with VILIP-1 level in predicting MCI was 0.852,which was higher than posterior cerebral artery stenosis rate and VILIP-1 alone(P<0.05).Conclusion Posterior cerebral artery stenosis rate combine with VILIP-1 level has good application value in predicting MCI in the elderly.

关 键 词：脑动脉狭窄程度 TAU蛋白 Β-淀粉样蛋白 视锥样蛋白-1 轻度认知功能障碍 

分 类 号：R749.1[医药卫生—神经病学与精神病学]