不同疾病伴发脑桥十字征的影像学特点及临床分析  

Clinical analysis and imaging features of hot cross bun sign in different diseases

作　　者：宋良[1] 付胜奇 张淑玲[1] 范文斐 周晓影 任雅芳 SONG Liang;FU Shengqi;ZHANG Shuling(Department of Neurology,The Fifth Clinical Medical College of Henan University of Chinese Medicine(Zhengzhou People’s Hospital)of Neurology,Zhengzhou 450003,China)

机构地区：[1]河南中医药大学第五临床医学院(郑州人民医院)神经内科,河南郑州450003

出　　处：《中风与神经疾病杂志》2022年第8期736-740,共5页Journal of Apoplexy and Nervous Diseases

基　　金：河南省医学科技攻关省部共建项目(SB201903029);河南省医学科技攻关项目(LHGJ20200683)。

摘　　要：目的探讨不同疾病与脑桥十字征(HCB)相关的临床表型,并确定神经影像学与临床特征之间的相关性。方法收集我院神经内科1例伴有HCB征患者资料,系统回顾已发表的关于脑桥十字征的病例,根据其病因共纳入14例病例并对其临床症状、影像学特点、治疗及预后等情况进行回顾性分析。结果通过系统文献回顾已发表病例,对疾病谱及其临床异质性进行分类。我们发现脑桥十字征与9种疾病谱相关,包括营养代谢性、炎性脱髓鞘性、神经系统变性病、肿瘤、副肿瘤、感染性、遗传相关性疾病、脑卒中和中毒。结论本研究表明,脑桥十字征的基础疾病谱可能比以前认识更广泛。根据临床表型、影像学特征和基础疾病的不同,HCBs的发生可能涉及不同的发病机制。Objective To explore the relevant clinical phenotype of different diseases relating to hot cross bun(HCB)sign and to determine the correlation between neuroimaging and clinical features.Methods Data of one patient with HCB syndrome in the Department of Neurology of our hospital were collected.The published cases of HCB syndrome were systematically reviewed.According to the etiology,14 cases were analyzed.The clinical symptoms,Magnetic resonance imaging(MRI)features,Laboratory examination treatment and prognosis and so forth were retrospectively analyzed.Results Published cases through the system references,classify disease and its clinical heterogeneity were reviewed.We found that HCB sign associated with 9 kinds of disease,including nutrition metabolic disease,inflammatory demyelinating disease,nervous system degenerative disease,secondary to suspected vasculitis Parkinson’s syndrome,tumor paraneoplastic disease testicular cancer is caused by the death of infectious diseases,genetic correlation disease related diseases,stroke and poisoning.Conclusion This study shows that the basic disease spectrum of HCB syndrome may be more extensive than before.According to different clinical phenotypes,imaging features and basic diseases,the occurrence of HCB may be involved in different pathogenesis.

关 键 词：脑桥十字征 神经系统变性病 脑卒中 

分 类 号：R743[医药卫生—神经病学与精神病学]