直肠癌患者术前PAB水平与临床病理特征及预后的关系  

Correlation between Preoperative PAB Level and Clinical and Pathological Characteristics in PABtients with Rectal Cancer

作　　者：陈岚[1] CHEN Lan(The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,471000)

机构地区：[1]河南科技大学第一附属医院,471000

出　　处：《实用癌症杂志》2022年第9期1491-1494,共4页The Practical Journal of Cancer

摘　　要：目的探究直肠癌患者术前血清前白蛋白(PAB)水平与临床病理特征及预后的关系。方法前瞻性选择298例直肠癌患者为病例组,同期选择298例体检健康者为对照组。比较2组血清PAB水平。比较不同肿瘤直径、组织学类型、组织分化程度、临床分期、淋巴结转移、脉管浸润、复发情况的直肠癌患者血清PAB水平,采用spearman相关分析血清PAB水平与直肠癌病理特征及复发情况的相关性。结果病例组血清PAB水平显著低于对照组(P<0.05)。临床分期Ⅲ~Ⅳ期、有淋巴结转移、有脉管浸润及复发直肠癌患者血清PAB水平显著低于临床分期Ⅰ~Ⅱ期、无淋巴结转移、无脉管浸润及无复发直肠癌患者,差异具有统计学意义(P<0.05);而不同组织分化程度、不同组织学类型及不同肿瘤直径直肠癌患者血清PAB水平对比,差异无统计学意义(P>0.05)。血清PAB水平与直肠癌患者肿瘤直径、组织学类型、组织分化程度无相关性(P>0.05);血清PAB水平与直肠癌患者临床分期、淋巴结转移、脉管浸润、复发呈负相关(P<0.05)。结论直肠癌患者术前血清PAB呈低水平状态,血清PAB水平与直肠癌患者临床分期、淋巴结转移、脉管浸润及复发密切相关,PAB有望成为评估直肠癌发生、进展及预后的生物标志物。Objective To investigate the correlation between preoperative prealbumin(PAB)level and clinical and pathological characteristics in patients with rectal cancer.Methods 298 patients with rectal cancer were prospectively selected as the case group and 298 healthy people were selected as the control group in the same period.The levels of serum PAB were compared between the 2 groups.The serum PAB levels of rectal cancer patients with different tumor diameter,histological type,degree of tissue differentiation,clinical stage,lymph node metastasis,vascular invasion and recurrence were compared.Spearman correlation was used to analyze the correlation between serum PAB level and pathological characteristics and recurrence of rectal cancer.Results The level of serum PAB in the case group was significantly lower than that in the control group(P<0.05).The level of serum PAB in patients with clinical stageⅢ~Ⅳ,lymph node metastasis and vascular invasion and recurrence was significantly lower than that in patients with clinical stageⅠ~Ⅱ,no lymph node metastasis and vascular invasion and recurrence(P<0.05);There were significant differences in serum PAB levels in rectal cancer patients with different degrees of tissue differentiation,different histological types and different tumor diameters(P<0.05).There was no correlation between serum PAB level and tumor diameter,histological type and degree of tissue differentiation in patients with rectal cancer(P>0.05);The level of serum PAB was negatively correlated with clinical stage,lymph node metastasis,vascular invasion and recurrence of rectal cancer patients(P<0.05).Conclusion Rectal cancer patients have low preoperative PAB levels,and PAB levels are closely related to clinical staging,lymph node metastasis,vascular infiltration and recurrence of rectal cancer patients,which can be expected to be a biomarker to evaluate the development and progression of rectal cancer.

关 键 词：直肠癌 前白蛋白 表达水平 病理特征 复发 相关性 

分 类 号：R735.37[医药卫生—肿瘤]