伴有攻击行为精神分裂症磁共振动态功能连接分析  

Dynamic functional connectivity analysis in resting-state fMRI:an application to schizophrenia patients with aggressive behaviors

作　　者：马洁华[1] 林倩倩 沈志华[1] 汪永光[1] MA Jiehua;LIN Qianqian;SHEN Zhihua;WANG Yongguang(Department of Brain Function-ing Research,The Seventh Hospital of Hangzhou,305 Tianmushan Road,Hangzhou 310013,China)

机构地区：[1]杭州市第七人民医院

出　　处：《中国神经精神疾病杂志》2022年第6期347-353,共7页Chinese Journal of Nervous and Mental Diseases

基　　金：国家自然科学基金面上项目(编号:81471366);浙江省科技厅公益技术研究项目(编号:LGF18H090023);杭州市科学技术局项目(编号:20190101A11,20180533B82)。

摘　　要：目的借助功能磁共振结合动态功能连接分析方法,探究伴有和不伴有攻击行为的精神分裂症患者动态脑功能连接状态的差异。方法招募17例伴有攻击行为的精神分裂症患者、29例不伴有攻击行为精神分裂症患者和26名健康对照,使用修改版外显攻击行为量表(modified overt aggression scale,MOAS)评估患者攻击行为,采集被试静息状态下的功能磁共振成像数据,进行动态功能连接分析,得到4个功能连接状态,提取不同功能连接状态间转换次数进行组间比较。结果伴有攻击行为组、不伴有攻击行为组、健康对照组间脑功能连接转换次数的中位数及上下四分位数分别为1.0(0.0,3.0)次、4.0(2.5,4.0)次和2.5(1.0,4.0)次,三组间存在统计学差异(H=14.411,P=0.001),其中伴有攻击行为组低于不伴有攻击行为组(P<0.001),不伴有攻击行为组高于健康对照组(P=0.041)。精神分裂症患者功能连接状态转换次数与MOAS财产攻击评分(r=-0.521,P<0.001)、体力攻击评分(r=-0.421,P=0.004)和MOAS加权总分(r=-0.519,P<0.001)呈负相关。结论精神分裂症患者攻击行为可能与其动态脑功能连接异常有关。Objective To explore the characteristics of dynamic functional connectivity changes in schizophrenic patients with aggressive behaviors.Methods Seventeen schizophrenic patients with aggressive behavior,twenty-nine schizophrenic patients without aggressive behavior and twenty-six healthy controls were included in the study.The Modified Overt Aggression Scale(MOAS)score was used to assess the severity of aggressive behavior in schizophrenia patients.The resting-state functional magnetic resonance imaging(fMRI)data of schizophrenic patients and healthy controls were collected.After fMRI data preprocessing,dynamic functional connectivity(dFC)analysis was performed to obtain four states.Finally,the differences on the number of functional connectivity state transitions from one state to another were evaluated between the two groups.Results There were significant differences in the number of transitions among schizophrenic patients with aggressive behavior,schizophrenic patients without aggressive behavior and healthy controls[1.0(0.0,3.0)vs.4.0(2.5,4.0)vs.2.5(1.0,4.0),H=14.411,P=0.001],of which the schizophrenic patients with aggressive behavior was lower than the schizophrenic patients without aggressive behavior(P<0.001),but the schizophrenic patients with aggressive behavior increased compared with the healthy controls(P=0.041).The number of transitions in schizophrenic patients was negatively correlated with property attack score(r=-0.521,P<0.001),physical attack score(r=-0.421,P=0.004)and weighted total score(r=-0.519,P<0.001)of MO AS.Conclusion These preliminary findings support that the aggression in schizophrenia is associated with abnormal the number of transitions of dFC states.

关 键 词：精神分裂症 攻击行为 功能磁共振 静息状态 动态功能连接分析 转换次数 组独立成分分析 

分 类 号：R749.3[医药卫生—神经病学与精神病学]