胃癌组织中SMARCC1和SMARCC2的水平及临床意义  

Levels of SMARCC1 and SMARCC2 in gastric cancer tissues and their clinical prognostic significance

作　　者：宋瑞[1] 胡怀远[1] 刘岩[1] 王怀新 SONG Rui;HU Huaiyuan;LIU Yan;WANG Huaixin(Department of Pathology,General Hospital of Wanbei Coal and Power Group,Suzhou 476100,China)

机构地区：[1]皖北煤电集团总医院病理科,安徽宿州234099 [2]合肥安为康医学检验实验室分子检测部,230000

出　　处：《临床肿瘤学杂志》2022年第8期721-726,共6页Chinese Clinical Oncology

摘　　要：目的探讨胃癌组织中SMARCC1和SMARCC2的水平及临床意义。方法选取2017年1月至2021年2月于本院进行胃癌手术的98例患者为研究对象,收集癌组织及对应的癌旁组织标本并采用实时荧光定量聚合酶链反应(qPCR)检测其中SMARCC1和SMARCC2的水平并分析两者在胃癌组织中的相关性,受试者工作特征(ROC)曲线分析两者诊断胃癌的效能,分层分析SMARCC1和SMARCC2的水平与胃癌临床病理特征和预后的关系。结果胃癌组织的SMARCC1和SMARCC2水平分别为3.688±0.127和4.179±0.186,高于癌旁组织的1.349±0.072和1.312±0.045,差异有统计学意义(P<0.05)。Pearson相关分析显示胃癌组织中SMARCC1水平与SMARCC2水平呈正相关(r=0.572,95%CI:0.422~0.692),差异有统计学意义(P<0.001)。ROC曲线分析显示,组织SMARCC1、SMARCC2水平诊断胃癌的曲线下面积分别为0.939(95%CI:0.908~0.971)、0.898(95%CI:0.844~0.952),当SMARCC1、SMARCC2截断值分别为2.632、2.292时约登指数最大,灵敏度和特异度分别为77.55%和95.52%及82.65%和96.94%。组织SMARCC1、SMARCC2水平与TNM分期、分化程度和浸润深度有关(P<0.05),SMARCC1水平还与肿瘤大小有关(P<0.05),而SMARCC2水平还与淋巴结转移有关(P<0.05)。SMARCC1、SMARCC2低水平者的中位总生存期分别为58.0、55.0个月,优于高水平者的26.0、36.0个月(HR=3.461,95%CI:1.888~6.347,P<0.001;HR=1.875,95%CI:1.052~3.340,P=0.033),进一步多因素分析发现组织SMARCC1水平升高是胃癌患者预后不良的危险因素(HR=2.954,95%CI:1.541~4.251,P=0.026)。结论胃癌组织中SMARCC1、SMARCC2水平升高,两者水平上调与胃癌的恶性行为相关,且SMARCC1是胃癌诊断和预后预测的潜在生物标志物。Objective To investigate the levels of SMARCC1 and SMARCC2 in gastric cancer tissues and their clinical prognostic significance.Methods Ninety-eight patients who underwent gastric cancer surgery in our hospital from January 2017 to February 2021 were selected as the study subjects.Cancer tissue specimens and corresponding paracancerous tissue specimens were collected.Levels of SMARCC1 and SMARCC2 were detected by real-time quantitative polymerase chain reaction(qPCR)and their correlation in gastric cancer tissues was analyzed.Efficacy of the two parameters in diagnosing gastric cancer was analyzed by receiver operating characteristic(ROC)curve.Relationships of levels of SMARCC1 and SMARCC2 with clinicopathological characteristics and prognosis of gastric cancer was analyzed hierarchically.Results Levels of SMARCC1 and SMARCC2 in gastric cancer tissues were 3.688±0.127 and 4.179±0.186,higher than 1.349±0.072 and 1.312±0.045 in paracancerous tissues with statistical significance(P<0.05).Pearson correlation analysis showed that SMARCC1 level was positively correlated with SMARCC2 level in gastric cancer(r=0.572,95%CI:0.422-0.692),and the difference was statistically significant(P<0.001).ROC curve analysis showed that the area under the curve of tissue SMARCC1 and SMARCC2 levels for the diagnosis of gastric cancer was 0.939(95%CI:0.908-0.971)and 0.898(95%CI:0.844-0.952).When the cutoff values of SMARCC1 and SMARCC2 were 2.632 and 2.292,the Jordan index was the largest with the sensitivity and specificity of 77.55%,95.52%and 82.65%,96.94%,respectively.Levels of SMARCC1 and SMARCC2 were related to TNM stage,differentiation and depth of invasion(P<0.05).Additionally,SMARCC1 level was also related to tumor size(P<0.05),and SMARCC2 level was also related to lymph node metastasis(P<0.05).The median overall survival of low-level SMARCC1 and SMARCC2 patients was 58.0 and 55.0 months,better than 26.0 and 36.0 months of high-level patients(HR=3.461,95%CI:1.888-6.347,P<0.001;HR=1.875,95%CI:1.052-3.340,P=0.033).Further multi

关 键 词：胃癌 SMARCC1 SMARCC2 临床意义 预后 

分 类 号：R735.2[医药卫生—肿瘤]