Asymmetric Transfer Hydrogenation of Diaryl Ketones with Ethanol Catalyzed by Chiral NCP Pincer Iridium Complexes  

作　　者：Lu Qian Xixia Tang Yulei wang Guixia Liu Zheng Huang 

机构地区：[1]School of Chemistry and Material Sciences,Hangzhou Institute of Advanced Study,University of Chinese Academy of Sciences,1 Sub-lane Xiangshan,Hangzhou,Zhejiang 310024,China [2]The State Key Laboratory of Organometllic Chemistry,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences,345 Lingling Road,Shanghai 200032,China [3]School of Physical Science and Technology,Shanghai Tech University,100 Haike Road,Shanghai 201210,China [4]Chang-Kung Chuang Institute,East China Normal University,Shanghai 200062,China

出　　处：《Chinese Journal of Chemistry》2022年第10期1131-1136,共6页中国化学（英文版）

基　　金：Financial support from the National Key R&D Program of China(2021YFA1501700,2021YFA1500100);the National Natural Science Foundation of China(22072178,21825109,21821002,21732006);the K.C.Wong Education Foundation,and Ningbo Municipal Bureau of Science and Technology(2019B10096)is gratefully acknowledged.

摘　　要：The use of a chiral(NCP)Ir complex as the precatalyst allowed for the discovery of asymmetric transfer hydrogenation of diaryl ketones with ethanol as the hydrogen source and solvent.This reaction was applicable to various ortho-substituted diaryl keontes,affording benzhydrols in good yields and enantioselectivities.This protocol could be carried out in a gram scale under mild reaction conditions.The utility of the catalytic system was highlighted by the synthesis of the key precursor of(S)-neobenodine.

关 键 词：Asymmetric transfer hydrogenation Benzhydrols Diaryl ketones ETHANOL IRIDIUM 

分 类 号：O621.251[理学—有机化学]