Enantioselective Reductive Cross-Coupling of Aryl/Alkenyl Bromides with Benzylic Chlorides via Photoredox/Biimidazoline Nickel Dual Catalysis  

作　　者：Tongtong Li Xiaokai Cheng Jiamin Lu Huifeng Wang Qun Fang Zhan Lu 

机构地区：[1]Department of Chemistry,Zhejiang University 866 Yuhangtang road,Hangzhou,Zhejiang 310058,China [2]College of Chemistry,ZhengzhouUniversity,Zhengzhou,Henan 450001,China [3]Hangzhou Innovation Center,Zhejang University,Hangzhou,Zhejiang 311200,China

出　　处：《Chinese Journal of Chemistry》2022年第9期1033-1038,共6页中国化学（英文版）

基　　金：Financial support was provided by the Zhejang Provincial Natural Science Foundation of China(No.LR19B020001);NSFC(Nos.21922107 and 21772171);the National Key R&D Program of China(Nos.2021YFA1500200 and 2021YFF0701603);the Center of Chemistry for Frontier Technologies.

摘　　要：The asymmetric reductive arylation and alkenylation of benzylic chloride under photoredox/nickel dual catalysis using chiral bimidazoline(Bilm)ligand is reported to access 1,1-diaryl alkanes and aryl allylic compounds with good yield as well as stereo-and enantioselectivities.This protocol uses more commercially available and less expensive C(sp^(2))-Br as the electrophile coupling partner.A primary result using alkenyl chloride and alkyl chloride is also reported.Various functional groups are tolerated and the applications of this method are investigated by late-stage functionalization and gram-scale reaction.

关 键 词：CROSS-COUPLING Photocatalysis ENANTIOSELECTIVITY STEREOSELECTIVITY Bimidazoline 

分 类 号：O643.36[理学—物理化学]