Chiral Dienes: From Ligands to FLP Catalysts  

作　　者：Xiangqing Feng Wei Meng Haifeng Du 

机构地区：[1]Beijing National Laboratory for Molecular Sciences,CAS Key Laboratory of Molecular Recognition and Function,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China [2]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Chinese Journal of Chemistry》2022年第9期1109-1116,共8页中国化学（英文版）

基　　金：We are grateful for the financial support from the National Natural Science Foundation of China(21521002 and 21825108).

摘　　要：Olefins are very easily accessible compounds which are both popular substrates in synthetic chemistry and good ligands in the organometallic complexes.This dual character makes olefins a rich source of chiral ligands and catalysts for asymmetric catalysis.Herein,we willbriefly summarize our studies on the development of chiral diene ligands for transition-metal catalyzed asymmetric reactions and chiral FLP catalysts for asymmetric metal-free hydrogenations and hydrosilylations.Several acyclic chiral diene ligands as well as P/olefin and S/olefin hybrid ligands were developed for Rh or Pd-catalyzed asymmetric reactions.With these ligands in hand,we further put forward a novel strategy for acquiring chiral FLP catalysts via the in situ hydroboration of chiral dienes with Piers'borane.These catalysts proved to be highly ffective for asymmetric metal-free hydrogenations and hydrosilylations of imines,ilyl enol ethers,ketones,and aromatic N-heterocycles.

关 键 词：Asymmetric catalysis Chiral dienes Frustrated Lewis pair Conjugated addition HYDROGENATION 

分 类 号：O62[理学—有机化学]