Finkler超声评分联合LMTK2基因在诊断上皮性卵巢癌中的应用  

Application of Finkler Ultrasound Score Combined with LMTK2 Gene in the Diagnosis of Epithelial Ovarian Cancer

作　　者：范方裕 蒲英梅[2] 周柱玉[2] 辛艳芬[2] 夏纪筑 FAN Fangyu;PU Yingmei;ZHOU Zhuyu;XIN Yanfen;XIA Jizhu(Southwest Medical University,School of Clinical Medicine,Luzhou 646000,Sichuan,P.R.China;Department of ultrasound,People’s Hospital of Deyang City,Deyang 618000,Sichuan,P.R.China)

机构地区：[1]西南医科大学临床医学院,四川泸州646000 [2]德阳市人民医院超声科,四川德阳618000

出　　处：《影像科学与光化学》2022年第5期1062-1066,共5页Imaging Science and Photochemistry

摘　　要：本文考察Finkler超声评分联合狐猴酪氨酸激酶2(LMTK2)基因在上皮性卵巢癌(EOC)诊断中的价值。本研究对112例EOC患者(EOC组)和76例卵巢良性上皮性肿瘤患者(良性组)进行超声检查及Finkler超声评分,并采用RT-PCR法检测血清LMTK2水平。结果显示,EOC组的Finkler超声评分和血清LMTK2 mRNA相对表达量显著高于良性组(P<0.001)。Finkler超声评分和血清LMTK2 mRNA相对表达量显著正相关(r=0.563,P<0.001)。当Finkler超声评分>5时,诊断EOC的曲线下面积(AUC)为0.964。当血清LMTK2 mRNA相对表达量>0.415时,诊断EOC的AUC为0.907。Finkler超声评分联合血清LMTK2诊断EOC的AUC(0.986)和敏感性(94.64%)高于单独诊断。Ⅲ~Ⅳ期组的Finkler超声评分和血清LMTK2 mRNA相对表达量显著高于Ⅰ~Ⅱ期组(P<0.05)。Finkler超声评分、血清LMTK2及二者联合诊断Ⅲ~Ⅳ期的AUC分别为0.643、0.850、0.851。本研究表明,在EOC的早期诊断中,与单独诊断相比,Finkler超声评分联合血清LMTK2可有效提高诊断灵敏度,并且血清LMTK2对病理分期的诊断价值可能高于Finkler超声评分。This paper investigated the value of Finkler ultrasound score combined with lemur tyrosine kinase 2(LMTK2)gene in the diagnosis of epithelial ovarian cancer(EOC).In this study,112patients with EOC (EOC group)and 76patients with benign epithelial tumor of ovary(benign group)underwent ultrasonography and Finkler ultrasound score,and detected the serumLMTK2levels by RT-PCR.The results showed that the Finkler ultrasound score and the relative expression of serumLMTK2 mRNA in the EOC group were significantly higher than those in the benign group(P<0.001).There was a significant positive correlation between the Finkler ultrasound score and the relative expression of serum LMTK2 mRNA (r=0.563,P<0.001).When the Finkler ultrasound score was>5,the area under curve(AUC)of the diagnosis of EOC was 0.964.When the relative expression of serumLMTK2 mRNA was>0.415,the AUC of diagnosing EOC was 0.907.The AUC(0.986)and sensitivity(94.64%)of Finkler ultrasound score combined with serumLMTK2 in the diagnosis of EOC were higher than those of single diagnosis.The Finkler ultrasound score and the relative expression of serumLMTK2 mRNA in stageⅢ-Ⅳgroup were significantly higher than those in stageⅠ-Ⅱgroup(P<0.05).The AUCs of Finkler ultrasound score,serumLMTK2 and their combined diagnosis of stageⅢ-Ⅳwere 0.643,0.850,and 0.851,respectively.This study showed that in the early diagnosis of EOC,compared with the single diagnosis,the Finkler ultrasound score combined with serum LMTK2 could effectively improve the diagnostic sensitivity,and the diagnostic value of serumLMTK2 for pathological staging could be higher than the Finkler ultrasound score.

关 键 词：上皮性卵巢癌 Finkler超声评分 狐猴酪氨酸激酶2 早期诊断 病理分期 

分 类 号：R737.31[医药卫生—肿瘤] R445.1[医药卫生—临床医学]