沙利度胺联用思密达保留灌肠治疗直肠癌术前放化疗致急性放射性直肠炎的临床观察  

Clinical Observation of Retention thalidomide combined with Mucosal Protective Agent retention enema on acute radiation proctitis caused by chemoradiotherapy after radical resection of rectal cancer

作　　者：钟妮 于毅[2] ZHONG Ni;YU Yi(Third District of Cancer,Chenzhou First People′s Hospital Affiliated to Nanhua University,Chenzhou 423000,China;Department of Hepatobiliary and Gastrointestinal Surgery,Chenzhou First People′s Hospital Affiliated to Nanhua University,Chenzhou 423000,China)

机构地区：[1]南华大学附属郴州市第一人民医院肿瘤三区,湖南郴州423000 [2]南华大学附属郴州市第一人民医院肝胆胃肠外科,湖南郴州423000

出　　处：《吉林医学》2022年第9期2402-2404,共3页Jilin Medical Journal

摘　　要：目的:探讨沙利度胺联用思密达在保留灌肠防治直肠癌术前放化疗致急性放射性直肠炎中的应用方法并观察其临床效果。方法:选取行直肠癌术前放化疗的患者81例,采用随机数字表法将其分为研究组41例与对照组40例。给予研究组患者沙利度胺联用思密达保留灌肠治疗,对照组则仅仅应用思密达保留灌肠治疗,就两组患者急性放射性直肠炎的发生率、同期放化疗耐受性以及睡眠、饮食、体重变化和KPS评分等临床指标进行分析与比较。结果:研究组患者急性放射性直肠炎的发生率明显低于对照组,且研究组的急性放射性直肠炎级别也明显低于对照组,差异均有统计学意义(P<0.05)。研究组患者在睡眠、饮食、体重以及KPS评分的改善上明显优于对照组,放疗中断率与总疗程均低于对照组,但化疗次数明显多于对照组,差异均有统计学意义(P<0.05)。结论:沙利度胺联用思密达保留灌肠的治疗方式更为安全有效,有利于降低患者急性放射性直肠炎的发生率,同时还可明显改善患者在放疗期间的生活质量。Objective To investigate the application of Salidamine in preoperative radiotherapy and chemotherapy before rectal cancer and observe its clinical effect. Method 81 patients who underwent preoperative chemoradiotherapy for rectal cancer were selected and divided into the study group 41 cases and the control group 40 cases by random number table method. Patients in the study group were treated with thalidomide combined with Smecta retention enema while those in the control group were treated with Smecta retention enema only. The incidence of acute radioactive rectitis, simultaneous tolerance of radiotherapy and chemotherapy, and sleep, diet, weight changes, and KPS scores were analyzed and compared.Results The incidence of acute radiation proctitis in the study group was significantly lower than that in the control group, and the level of acute radiation proctitis in the study group was also significantly lower than that in the control group, with a statistically significant difference(P<0.05). The improvement of sleep, diet, body weight and KPS score in the study group was significantly better than that in the control group. The interruption rate of radiotherapy and the total course of treatment were lower than that in the control group, but the number of chemotherapy was significantly higher than that in the control group, and the difference was statistically significant(P<0.05).Conclusion Thalidomide combined with retention enema of triethanolamine cream can prevent and treat acute radiation proctitis caused by radiotherapy after radical resection of rectal cancer, as well as improve the quality of life.

关 键 词：直肠癌 沙利度胺 蒙脱石散 地塞米松 急性放射性直肠炎 

分 类 号：R735.37[医药卫生—肿瘤]