牡丹皮化学成分、药理作用及其质量标志物(Q-Marker)的预测分析  

Chemical constituents,pharmacological effects of Moutan Cortex and predictive analysis on its quality marker(Q-Marker)

作　　者：张树蓉 赵宏苏 佟沫儒 熊俊伟 王雪 巫梦莹 翟宏焱 吴德玲 张村[5] 张伟 ZHANG Shu-rong;ZHAO Hong-su;TONG Mo-ru;XIONG Jun-wei;WANG Xue;WU Meng-ying;ZHAIHong-yan;WU De-ling;ZHANG Cun;ZHANG Wei(College of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,China;Anhui Province Key Laboratory of Traditional Chinese Medicine Decoction Pieces of New Manufacturing Technology,Hefei 230012,China;Anhui Institute for Food and Drug Control,Hefei 230012,China;NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine,Hefei 230051,China;Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]安徽中医药大学药学院,安徽合肥230012 [2]中药饮片制造新技术安徽省重点实验室,安徽合肥230012 [3]安徽省食品药品检验研究院,安徽合肥230012 [4]国家药品监督管理局中药质量研究与评价重点实验室,安徽合肥230051 [5]中国中医科学院中药研究所,北京100700

出　　处：《中草药》2022年第16期5215-5224,共10页Chinese Traditional and Herbal Drugs

基　　金：国家重点研发计划中医药现代化研究专项(2018YFC1707004);安徽省药品监督管理局药品监管科技创新项目(AHYJ-KJ-202102)。

摘　　要：牡丹皮首载于《神农本草经》,具有清热凉血、活血化瘀的功效,是临床常用的清热凉血药,其化学成分主要包括苯乙酮类、萜类及其苷类、有机酸类以及其他类成分,具有抗炎、调节免疫功能、保护心血管等作用。通过分析牡丹皮植物亲缘学、化学成分特有性证据、化学成分可测性等的关系,对牡丹皮的质量标志物(quality marker,Q-Marker)进行分析,并预测丹皮酚、芍药苷、没食子酸、苯甲酰芍药苷、苯甲酰氧化芍药苷、氧化芍药苷、1,2,3,4,6-O-五没食子酰葡萄糖、丹皮酚原苷、丹皮酚新苷、牡丹皮苷C、苯甲酸等可作为其Q-Markers,以期为牡丹皮质量评价体系的建立提供参考。Mudanpi(Moutan Cortex)was first recorded in“Shen Nong’s Materia Medica”.It has the effects of clearing heat and cooling blood,promoting blood circulation and removing blood stasis.It is a commonly used clinical medicine for clearing heat and cooling blood.Its chemical components mainly include acetophenones,terpenes and their glycosides,organic acids and other components,which have anti-inflammatory,immune function,and cardiovascular protection effects.By analyzing the relationship between plant genetics,chemical composition specificity evidence,chemical composition measurability,etc.,the quality markers(Q-Markers)of Moutan Cortex were analyzed from various aspects,and the prediction of paeonol,paeoniflorin,gallic acid,benzoylpaeoniflorin,benzoyloxypaeoniflorin,oxypaeoniflorin,1,2,3,4,6-O-pentagalloylglucose,paeonolide,apiopaeonoside,mudanpioside C,benzoic acid etc.can be used as its QMarkers,in order to provide a reference for the establishment of quality evaluation system of Moutan Cortex.

关 键 词：牡丹皮 质量标志物 丹皮酚 芍药苷 没食子酸 苯甲酰芍药苷 苯甲酰氧化芍药苷 氧化芍药苷 1 2 3 4 6-O-五没食子酰葡萄糖 丹皮酚原苷 丹皮酚新苷 牡丹皮苷C 苯甲酸 

分 类 号：R282.710.5[医药卫生—中药学]