Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in Mice  

作　　者：Yoona Oh Hongbum Lee Beodeul Yang Sura Kim Hyunwoo Jeong Hyungwoo Kim 

机构地区：[1]Division of Pharmacology,School of Korean Medicine,Pusan National University,Gyeongnam,50612,South Korea [2]Department of Pathology,College of Korean Medicine,Dongshin University,Jeonnam,58245,South Korea

出　　处：《Chinese Journal of Integrative Medicine》2022年第8期719-724,共6页中国结合医学杂志（英文版）

基　　金：Supported by the National Research Foundation of Korea funded by the Korean Government(MSIP,No.2018R1A2B6006031)。

摘　　要：Objective:To investigate the anti-inflammatory potential of Ampelopsis japonica on contact dermatitis(CD).Methods:A total of 38 Balb/c mice were divided into 5 groups by using a random number table:normal mice(n=6),CID model mice(n=8),CD mice treated with 3 or 30 mg/kg of the ethanol extract of A.japonica(EEAJ,n=8)and 7.5 mg/kg dexamethasone treated CD mice(DEX,n=8).CD was induced using topical application of 1-fluoro-2,4-dinitrofluorobenzene in mice.EEAJ and DEX were topically applied to the shaved skin of each mouse for 6 days,and the effects of EEAJ and DEX on skin lesions and color,histopathological abnormalities such as epidermal hyperplasia and immune cell infiltration,and tumor necrosis factor(TNF)-α,interleukin-6(IL-6),and monocyte chemoattractant protein-1(MCP-1)production were investigated.The effects on changes in body weights and spleen/body weight ratio were also investigated.Results:EEAJ at 30 mg/kg significantly prevented scaling,erythema and enlargement of skin weight compared to using carbon dioxide.EEAJ also prevented epithelial hyperplasia and immune cell infiltrations induced by repeated application of DNFB(P<0.01).In addition,EEAJ significantly lowered levels of TNF-α,IL-6 and MCP-1(P<0.05 or P<0.01).The anti-inflammatory effects of EEAJ were similar to those of DEX.Conclusion:A.japonica may be a new therapeutic agent with the potential to reduce or replace corticosteroids and its mechanisms are closely related to regulation of TNF-α production.

关 键 词：Ampelopsis japonica Chinese medicine INFLAMMATION DERMATOSIS contact dermatitis 

分 类 号：R285.5[医药卫生—中药学]