不同状态-特质焦虑水平Wilson病患者的注意偏向特征  

Characteristics of attentional bias in Wilson disease patients with different levels of state-trait anxiety

作　　者：施倍倍 王共强 马心锋 张龙 韩咏竹 Shi Beibei;Wang Gongqiang;Ma Xinfeng;Zhang Long;Han Yongzhu(Graduate School of Anhui University of Chinese Medicine,Hefei 230038,China;Affiliated Hospital of Institute of Neurology of Anhui University of Chinese Medicine,Hefei 230061,China)

机构地区：[1]安徽中医药大学研究生院,合肥230038 [2]安徽中医药大学神经病学研究所附属医院,合肥230061

出　　处：《中华行为医学与脑科学杂志》2022年第8期698-702,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：安徽中医药大学临床科研重大项目(2020sjzd02)。

摘　　要：目的探讨Wilson病(Wilson disease,WD)患者不同状态-特质焦虑水平的注意偏向特征。方法采用情绪Stroop范式及状态-特质焦虑量表(state-trait anxiety inventory,STAI)评估49例WD患者焦虑水平及注意偏向变化特点。采用SPSS 25.0进行统计分析,两组间比较采用独立样本t检验,多元线性回归分析评估注意偏向反应时的影响因素。结果(1)WD患者高特质焦虑组分别在正性、负性及中性词刺激下测得的反应时[分别为(867.0±172.1)ms、(877.0±167.7)ms、(898.4±169.8)ms]明显高于低特质焦虑组[分别为(771.9±128.9)ms、(770.9±110.4)ms、(778.4±120.1)ms],均差异有统计学意义(t=-2.183,-2.605,-2.847,均P<0.05)。高状态焦虑组分别在正性、负性及中性词刺激下的反应时[分别为(866.9±171.9)ms、(867.8±173.8)ms、(889.8±173.5)ms]高于低状态焦虑组[分别为(771.9±129.2)ms、(780.4±109.3)ms、(787.3±123.0)ms],均差异有统计学意义(t=-2.177,-2.116,-2.378,均P<0.05)。(2)多元线性回归分析显示,特质焦虑总分(B=4.584、4.671、5.376,P=0.020、0.015、0.008)及年龄(B=9.314、7.864、7.505,P=0.002、0.008、0.014)是正性、负性情绪词及中性词刺激下反应时的影响因素。结论焦虑情绪会导致WD患者表现出更多的负性注意偏向,且特质焦虑能够显著预测注意偏向的特征。Objective To investigate the characteristics of attention bias in Wilson disease(WD)patients with different levels of state-trait anxiety.Methods The emotional Stroop paradigm and the state-trait anxiety inventory(STAI)were used to evaluate the anxiety level and the characteristics of attention bias in 49 inpatients with WD.SPSS 25.0 software was used for statistical analysis.Independent sample t-test was used for comparison between the two groups.Multiple linear regression analysis was used to evaluated the influencing factors of attentional bias response time.Results(1)In WD patients,the response times measured under the positive,negative and neutral words in the high trait anxiety group((867.0±172.1)ms,(877.0±167.7)ms,(898.4±169.8)ms,respectively)were significantly higher than the low trait anxiety group((771.9±128.9)ms,(770.9±110.4)ms,(778.4±120.1)ms,respectively)and the differences were statistically significant(t=-2.183,-2.605,-2.847,all P<0.05).The response times under the positive,negative and neutral word measured in the high state anxiety group((866.9±171.9)ms,(867.8±173.8)ms,(889.8±173.5)ms,respectively)were higher than those of the low state anxiety group((771.9±129.2)ms,(780.4±109.3)ms,(787.3±123.0)ms,respectively)and the differences were statistically significant(t=-2.177,-2.116,-2.378,all P<0.05).(2)Multiple linear regression analysis showed that the total score of trait anxiety(B=4.584,4.671,5.376,P=0.020,0.015,0.008)and age(B=9.314,7.864,7.505,P=0.002,0.008,0.014)were the influencing factors of response times measured under the positive,negative and neutral emotion words.Conclusion Anxiety will lead patients with WD to show more negative attention bias,and trait anxiety can significantly predict the characteristics of attention bias.

关 键 词：WILSON病 肝豆状核变性 注意偏向 情绪Stroop范式 状态-特质焦虑 

分 类 号：R749[医药卫生—神经病学与精神病学]